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Mansoori, Maryam,Golalipour, Masoud,Alizadeh, Shahriar,Jahangirerad, Ataollah,Khandozi, Seyed Reza,Fakharai, Habibollah,Shahbazi, Majid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: One of the major mechanisms for drug resistance is associated with altered anticancer drug transport, mediated by the human-adenosine triphosphate binding cassette (ABC) transporter superfamily proteins. The overexpression of adenosine triphosphate binding cassette, sub-family B, member 1 (ABCB1) by multidrug-resistant cancer cells is a serious impediment to chemotherapy. In our study we have studied the possibility that structural single-nucleotide polymorphisms (SNP) are the mechanism of ABCB1 overexpression. Materials and Methods: A total of 101 gastric cancer multidrug resistant cases and 100 controls were genotyped with sequence-specific primed PCR (SSP-PCR). Gene expression was evaluated for 70 multidrug resistant cases and 54 controls by real time PCR. The correlation between the two groups was based on secondary structures of RNA predicted by bioinformatics tool. Results: The results of genotyping showed that among 3 studied SNPs, rs28381943 and rs2032586 had significant differences between patient and control groups but there were no differences in the two groups for C3435T. The results of real time PCR showed over-expression of ABCB1 when we compared our data with each of the genotypes in average mode. Prediction of secondary structures in the existence of 2 related SNPs (rs28381943 and rs2032586) showed that the amount of ${\Delta}G$ for original mRNA is higher than the amount of ${\Delta}G$ for the two mentioned SNPs. Conclusions: We have observed that 2 of our studied SNPs (rs283821943 and rs2032586) may elevate the expression of ABCB1 gene, through increase in mRNA stability, while this was not the case for C3435T.
Mansoori, Abdul Anvesh,Jain, Subodh Kumar Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Chronic alcohol and tobacco abuse plays a crucial role in the development of different liver associated disorders. Intake promotes the generation of reactive oxygen species within hepatic cells exposing their DNA to continuous oxidative stress which finally leads to DNA damage. However in response to such damage an entangled protective repair machinery comprising different repair proteins like ATM, ATR, H2AX, MRN complex becomes activated. Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including hepatocellular carcinomas. The generated reactive oxygen species can also activate or repress epigenetic elements such as chromatin remodeling, non-coding RNAs (micro-RNAs), DNA (de) methylation and histone modification that affect gene expression, hence leading to various disorders. The present review provides comprehensive knowledge of different molecular mechanisms involved in gene polymorphism and their possible association with alcohol and tobacco consumption. The article also showcases the necessity of identifying novel diagnostic biomarkers for early cancer risk assessment among alcohol and tobacco users.
Multiple Brillouin Stokes Generation Utilizing a Linear Cavity Erbium-Doped Fiber Laser
AL-Mansoori, Mohammed Haydar,Noordin, Nor Kamariah,Saripan, M. Iqbal,Mahdi, Mohd Adzir The Korea Institute of Information and Commucation 2008 Journal of communications and networks Vol.10 No.1
This paper reports the design of a multiwavelength fiber laser source that utilizes a linear cavity of hybrid Brillouin/Erbium fiber laser (BEFL). The output power, threshold power and free running cavity modes were investigated against the pump powers. The structure exhibited low threshold operation of 4 mW at 2.3 mW injected Brillouin pump power. The optimization of Brillouin pump wavelength, power and Erbium gain led to a maximum possible number of channels generated. Simultaneous and stable operation of 21 channels with 10.88 GHz channels spacing were obtained from this architecture at 1 mW injected Brillouin pump power and 90 m W Erbium doped fiber pump power in the 1555 nm region.
Y. Mansoori,Atghia S. V.,S. Shah Sanaei,M. R. Zamanloo,Imanzadeh Gh. 한국고분자학회 2010 Macromolecular Research Vol.18 No.12
This paper reports the grafting of poly(methyl methacrylate) (PMMA) onto organophilic montmorillonite (Cloisite 20). Cloisite 20A was reacted with vinyltrichlorosilane to replace the edge hydroxyl groups of the clay with a vinyl moiety. Under the reaction condition, the exchange of quaternary alkylammonium cations with H+ ions was prevented and only the silanol groups on the edge of the clay reacted with vinyltrichlorosilane. The radical polymerization of the product with methyl methacrylate as a vinyl monomer led to the chemical grafting of PMMA onto the montmorillonite surface. Chemical grafting of the polymer onto Cloisite 20A was confirmed by Infrared (IR) spectroscopy after Soxhelt extraction. The interlayer and surface changes to the clay in the prepared nanocomposite materials and the grafted nano-particles were examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The intercalated nanocomposites were obtained for clay contents up to 5%. The nanocomposites were examined by thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMTA). Nanocomposites exhibit a higher glass transition temperature and improved thermal properties than neat PMMA due to an interaction between the PMMA matrix and PMMA-grafted clay particles.