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- 저자 : Manqian Xiao (검색결과 1 건)
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Associations among Genetic Variants and Intracranial Aneurysm in a Chinese Population
Bingyang Li,Chongyu Hu,Junyu Liu,Xin Liao,Jiayu Xun,Manqian Xiao,Junxia Yan 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.7
Purpose: Genome-wide association studies (GWAS) have revealed that common variants on or near EDNRA, HDAC9, SOX17,RP1, CDKN2B-AS1, and RBBP8 genes are associated with intracranial aneurysm (IA) in European or Japanese populations. However,due to population heterogeneity, whether these loci are associated with IA pathogenesis in Chinese individuals is still unknown. The purpose of this study was to investigate associations among GWAS-identified loci and risk of IA in a Chinese population. Materials and Methods: A total of 765 individuals (including 230 IA patients and 535 controls) were involved in this study. Twelvesingle nucleotide polymorphisms (SNPs) of candidate loci were genotyped using the Sequenom MassARRAY platform. Associationswere analyzed using univariate or multivariate logistic regression analysis. Results: SNPs in CDKN2B-AS1 (especially rs10757272) showed significant associations with IA in dominant and additive models[odds ratio (OR), 2.99 and 1.43; 95% confidence interval (CI), 1.44–6.24 and 1.10–1.86, respectively]. A SNP near HDAC9 (rs10230207)was associated with IA in the dominant model (OR, 1.42; 95% CI, 1.01–1.99). One SNP near RP1 (rs1072737) showed a protectiveeffect on IA in the dominant model (OR, 0.66; 95% CI, 0.46–0.95), while another SNP in RP1 (rs9298506) showed a risk effect onIA in a recessive model (OR, 3.82; 95% CI, 1.84–7.91). No associations were observed among common variants near EDNRA,SOX17, or RBBP8 and IA. Conclusion: These data partially confirmed earlier results and showed that variants in CDKN2B-AS1, RP1, and HDAC9 could begenetic susceptibility factors for IA in a Chinese population.
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