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Development of novel cascade type crystallizer for continuous production of crystalline particles
Mana Koyama,Shoji Kudo,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
The introduction of a continuous crystallization process has been attracting attention for thepharmaceutical products. We designed a novel continuous crystallizer, which includes Couette–Taylorequipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions weresupplied to MSMPR and Couette–Taylor equipment toflexibly control the supersaturation of the MSMPRequipment, regardless of the supersaturation of Couette–Taylor equipment. In this study, the relationshipbetween operating parameters in novel cascade–type crystallizer andfinal crystal quality wasinvestigated. We found that the quality of the obtained crystalline particles depend on theflow-rate ratioof the feed solution supplied to Couette–Taylor equipment. Furthermore, the yield of crystalline productswas improved using proposed crystallizer. Therefore, we expect proposed novel cascade–typecrystallizer consisting of Couette–Taylor and MSMPR equipment to obtain crystalline products withvarious quality.