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Flavonoids of Gomphocarpus sinaicus and Evaluation of Some Pharmacological Activities
Seham. A. El Batran,N. S. Abdel-Azim,K. A. Abdel-Shafeek,A. A. Shahat,M.M. El-Missiry 한국생약학회 2005 Natural Product Sciences Vol.11 No.4
The aerial parts of Gomphocarpus sinaicus Boiss. yielded four flavonoids that were identified asisorhamnetin 3-O-rhamnoglucoside (1), luteolin-7-O-glucoside-3-O-rhamnoside (2), rutin (3) and rutin-7-O-rhamnoside (4). All of the isolated flavonoids were identified by spectroscopic methods (UV, FAB-MS, 1H-NMR& 13C-NMR) and in comparison with the literature data. The isolated flavonoids 1, 2 and 4 are reported here forthe first time from Gomphocarpus sinaicus Boiss. Three sets of experiments were carried out using the defattedalcoholic extract of Gomphocarpus sinaicus Boiss: the 1st experiment indicated that the LD50 was 49.82 mg/100 gb.wt. of intraperitoneally (i.p.) injected mice. The toxic signs were recorded within the first 24 hr post-injection.The 2nd experiment revealed that the extract of the plant exhibited significant anti-inflammatory effects in normalrats. The 3rd experiment was found that the tested doses of the extract in diabetic rats induced a significant decreasein serum glucose, AST, ALT, triglycerides, cholesterol and LDL, while HDL caused a significant increase.