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European Laboratories for Pulsed Power Research
Emil Spahn,Markus-Jan Loffler,Saulius Balevicius 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
In this paper, the newly founded European Pulsed Power Laboratories (EPPL) will be introduced. The objective of this initiative is to bundle the resources of the involved institutions and to bring together research and expertise of Europe뭩 principal pulsed power laboratories with the goals to minimize the overlap of research, to achieve a critical mass and to establish a European network. The pulsed power topics of EPPL cover a broad range. Besides pulsed power components, complete pulsed power systems are studied as well. In the area of pulsed power applications, both military and civilian (commercial) ones are envisaged.
Kim, Taek-Hyeon,Na, Hye-Sun,Loffler, Monika The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.3
Novel $\beta$-hydroxy propenamides as analogues of the active metabolite of leflunomide (A 771726) were synthesized and evaluated for their inhibitory activity on dihydroorotate dehydrogenase (DHODH) in an investigation into their immunosuppressive activity. Compounds 2a, 3a, and 3h were approximately 4-40 times more potent than leflunomide in their activity while they were-less active than A 771726.
Yoon, Sukhwan,Nissen, Silke,Park, Doyoung,Sanford, Robert A.,Loffler, Frank E. American Society for Microbiology 2016 Applied and environmental microbiology Vol.82 No.13
<P>Bacteria capable of reduction of nitrous oxide (N2O) to N-2 separate into clade I and clade II organisms on the basis of nos operon structures and nosZ sequence features. To explore the possible ecological consequences of distinct nos clusters, the growth of bacterial isolates with either clade I (Pseudomonas stutzeri strain DCP-Ps1, Shewanella loihica strain PV-4) or clade II (Dechloromonas aromatica strain RCB, Anaeromyxobacter dehalogenans strain 2CP-C) nosZ with N2O was examined. Growth curves did not reveal trends distinguishing the clade I and clade II organisms tested; however, the growth yields of clade II organisms exceeded those of clade I organisms by 1.5- to 1.8-fold. Further, whole-cell half-saturation constants (K(s)s) for N2O distinguished clade I from clade II organisms. The apparent Ks values of 0.324 +/- 0.078 mu M for D. aromatica and 1.34 +/- 0.35 mu M for A. dehalogenans were significantly lower than the values measured for P. stutzeri (35.5 +/- 9.3 mu M) and S. loihica (7.07 +/- 1.13 mu M). Genome sequencing demonstrated that Dechloromonas denitrificans possessed a clade II nosZ gene, and a measured Ks of 1.01 +/- 0.18 mu M for N2O was consistent with the values determined for the other clade II organisms tested. These observations provide a plausible mechanistic basis for why the relative activity of bacteria with clade I nos operons compared to that of bacteria with clade II nos operons may control N2O emissions and determine a soil's N2O sink capacity.</P>