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Xiandi Zhang,Zhifeng Shi,Yuanxin Xie,Yong Wang,Chao Shen,Zengxin Qi,Liqiong Zhang,Bojie Yang,Jinhua Yu,Hong Ding 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.4
Purpose: The relationship between contrast-enhanced ultrasound (CEUS) hemodynamics and the molecular biomarkers of adult-type diffuse gliomas, particularly isocitrate dehydrogenase (IDH), remains unclear. This study was conducted to provide a comprehensive description of the vascularization of adult-type diffuse gliomas using quantitative indicators. Additionally, it was designed to identify any variables with the potential to intraoperatively predict IDH mutation status. Methods: This prospective study enrolled patients with adult-type diffuse gliomas between November 2021 and September 2022. Intraoperative CEUS was performed, and CEUS videos were recorded for 90-second periods. Hemodynamic parameters, including the peak enhancement (PE) difference, were calculated based on the time-intensity curve of the region of interest. A differential analysis was performed on the CEUS parameters with respect to molecular biomarkers and grades. Receiver operating characteristic curves for various parameters were analyzed to evaluate the ability of those parameters to predict IDH mutation status. Results: Sixty patients with adult-type diffuse gliomas were evaluated. All hemodynamic parameters, apart from rising time, demonstrated significant differences between IDH-mutant and IDH-wildtype adult-type diffuse gliomas. The PE difference emerged as the optimal indicator for differentiating between IDH-wildtype and IDH-mutant gliomas, with an area under the curve of 0.958 (95% confidence interval, 0.406 to 0.785). Additionally, the hemodynamic parameters revealed significant differences across both grades and types of adult-type diffuse gliomas. Conclusion: Hemodynamic parameters can be used intraoperatively to effectively distinguish between IDHwildtype and IDH-mutant adult-type diffuse gliomas. Additionally, quantitative CEUS equips neurosurgeons with dynamic perfusion information for various types and grades of adult-type diffuse gliomas.
Jiang Yu,Yang Yu,Tingting Zhang,Liqiong Zheng 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.7
The photodegradation of hydrogen sulfide (H2S) was examined using a self-made microwave electrodeless discharge lamp (MEDL). The features of the MEDL had been tested. The results showed that the MEDL absorbed 18.3, 32.7 and 41.8W power at the microwave (MW) output power of 165, 330 and 660W, respectively. The intensity of the emitted light increased with increasing MW output power. The reactive oxygen species (ROS) generated by irradiated air and nitrogen were detected, respectively. It was illustrated that the irradiated air could generate a number of ROS, at least including 1O2 and •OH. And the amount of ROS increased with increasing MW output power. In photodegradation of H2S process, the effects of MW output power and gas composition were investigated. The removal efficiency of H2S under nitrogen was obviously lower compared with that under air. The removal efficiency of H2S increased with increasing MW output power.