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Xiaoyang Hou,Lilan Huang,Han Zhang,Qingping Xin,Hong Li,Hui Ye,Yuzhong Zhang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.123 No.-
Accumulation of endogenous and exogenous toxins in patients with chronic kidney disease increases thekidney burden. The newly developed plasma separation adsorption membranes provide a new model forthe removal of middle molecular toxins. In this study, the adsorption resin LX-1000H is physically pulverizedand blended into polyethersulfone matrixes to prepare adsorption resin/polyethersulfone (AR/PES) membranes by nonsolvent-induced phase separation for plasma separation and middle moleculartoxins absorption. The results show that the static adsorption capacity of AR/PES membrane for lysozyme(a typical mimic of middle molecular toxins) is up to 108.90 mg/g, which is 4 times that of AR. The maximumdynamic adsorption capacity reaches 102.80 mg/g, which is 93.4% of static adsorption. The adsorptionprocess is more consistent with the Langmuir model and the quasi-first-order kinetic model. Thepermeability of bovine serum albumin in simulated blood surpasses 90% and the cattle blood separatedby AR/PES membrane is colorless and transparent. The AR/PES membrane surface presents electronegativeat pH 7.4 and the water wettability is enhanced with the doping amount. No hemolysis and negligibleleakage indicated favorable hemocompatibility. This paper is devoted to providing a strategy forplasma separation and adsorption membranes.