Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

Yingming Wei,Zhongxiu Wang,Jiayin Han,Xiaojian Jiang,Lihong Lei,Xianyan Yang,Weilian Sun,Zhongru Gou,Lili Chen 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Destruction of alveolar bone and periodontal ligament due to periodontal disease often requires surgical treatment to reconstruct the biological construction and functions of periodontium. Despite significant advances in dental implants in the past two decades, it remains a major challenge to adapt bone grafts and barrier membrane in surgery due to the complicated anatomy of tooth and defect contours. Herein, we developed a novel biphasic hierarchical architecture with modularized functions and shape based on alveolar bone anatomy to achieve the ideal outcomes. Methods: The integrated hierarchical architecture comprising of nonstoichiometric wollastonite (nCSi) scaffolds and gelatin methacrylate/silanized hydroxypropyl methylcellulose (GelMA/Si-HPMC) hydrogel membrane was fabricated by digital light processing (DLP) and photo-crosslinked hydrogel injection technique respectively. The rheological parameters, mechanical properties and degradation rates of composite hydrogels were investigated. L-929 cells were cultured on the hydrogel samples to evaluate biocompatibility and cell barrier effect. Cell scratch assay, alkaline phosphatase (ALP) staining, and alizarin red (AR) staining were used to reveal the migration and osteogenic ability of hydrogel membrane based on mouse mandible-derived osteoblasts (MOBs). Subsequently, a critical-size one-wall periodontal defect model in dogs was prepared to evaluate the periodontal tissue reconstruction potential of the biphasic hierarchical architecture. Results: The personalized hydrogel membrane integrating tightly with the nCSi scaffolds exhibited favorable cell viability and osteogenic ability in vitro, while the scratch assay showed that osteoblast migration was drastically correlated with Si-HPMC content in the composite hydrogel. The equivalent composite hydrogel has proven good physiochemical properties, and its membrane exhibited potent occlusive effect in vivo; meanwhile, the hierarchical architectures exerted a strong periodontal regeneration capability in the periodontal intrabony defect models of dogs. Histological examination showed effective bone and periodontal ligament regeneration in the biomimetic architecture system; however, soft tissue invasion was observed in the control group. Conclusions: Our results suggested that such modularized hierarchical architectures have excellent potential as a next-generation oral implants, and this precisely tuned guided tissue regeneration route offer an opportunity for improving periodontal damage reconstruction and reducing operation sensitivity.

Research on soil net nitrogen mineralization in Stipa grandis grassland with different stages of degradation

Wanyu Wen,Xiaobing Li,Lihong Chen,Dandan Wei,Han Wang,Meng Zhang,Jing Yu 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.4

Net nitrogen mineralization is one of the nitrogen cycling process, and it is very important to understand nitrogen mineralization characteristics in degradation grassland. In the upper 0–10 cm soil layer of Stipa grandis P. A. Smirn. grassland in the Xilin river basin, Inner Mongolia, we studied the soil net nitrogen mineralization and nitrification among three varying stages of degradation grassland and analyzed the relationship between the mineralization rate of the soil net nitrogen and environmental factors, using the resin-core incubation method. Our results demonstrated that, from May to October 2012, the accumulated net nitrogen mineralization was 21.620 mg kg–1, 12.486 mg kg–1, and 48.053 mg kg–1 in the slightly, medium, and heavily degraded grasslands, respectively and varied greatly among the three stages of degradation shown by the S. grandis grassland plots. During the cultivation period, the variation of net nitrogen mineralization and nitrification was similar to the variation of soil mineral nitrogen. The higher soil mineral nitrogen content indicated higher mineralization of net nitrogen. In July and August, soil moisture was positively correlated with the net nitrogen mineralization rate, and the correlation coefficients between these two factors of 0.73, 0.58, and 0.79 for the slightly, medium, and heavily degraded plots, respectively. The rates of net nitrogen mineralization and nitrification were negatively correlated with soil total nitrogen, but positively correlated with C/N ratio, and weakly correlated with other physicochemical properties.

A Node Importance Measuring Method based on Hypernetwork

Quan Xiao,Fangli Yang,Song Luo,Lihong Zhang,Hua Zhao,Wei Shu 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12

Measuring the importance of nodes in network is an important issue in the study of complex networks. The networks in current researches are mostly based on classical graph theory, which have limitations on describing certain complex relations. In this work, we introduce hypernetwork, taking hypergraph as representation foundation, to describe relations. Hypernetwork is able to extend the modeling and describing capability of traditional network and may be a promising representation model of complex relations. However, a general lack of attention to the node importance measuring in hypernetwork, an important fundamental issue for its further application, has been noted across the majority of related published works. In this paper, we utilize the idea of deleting method, to measure the importance of node in hypernetwork through investigating the influence on the whole network when deleting it. Specifically, the influence is measured by direct loss and indirect loss. Through a calculating example, our method is compared with node degree, betweenness, closeness centrality, degree of neighbor nodes etc., the result shows this method has better adaptability and accuracy.

Trend-GRU Model based Time Series Data Prediction in Melt Transport Process

Dongqi Zhao,Kuangrong Hao,Lei Chen,Bing Wei,Xue-Song Tang,Xin Cai,Lihong Ren 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10

Temperature and pressure are two important performance indicators during the melt transport of polyester fiber production, which can affect the overall properties of the melt. Therefore, the accurate prediction of these two indicators is crucial for the control of melt properties. This paper proposes a data prediction model, Trend-GRU (Gated Recurrent Unit), which can extract the feature of unstable change of the melt data. On the premise that the model is not over-complicated, a new structure is designed to extract the feature of unstable change to improve the prediction accuracy. Two data sets on temperature and pressure collected from the actual production process of a spinning factory are used for comparative experiments. The results show that the accuracy of the data prediction of the proposed model is better than the original one.

Association between hearing loss and physical performance in patients on maintenance hemodialysis

Fan Weifeng,Zhong Xiaojing,Wu Qing,Zhang Lihong,Yang Zhenhao,Gu Yong,Guo Qi,Chen Xiaoyu,Yu Chen,Zhang Kun,Ding Wei,Qi Hualin,Zhao Junli,Zhang Liming,Zhang Suhua,Niu Jianying 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.3

Background: The correlation between hearing loss (HL) and physical performance in patients receiving maintenance hemodialysis (MHD) remains poorly investigated. This study explored the association between HL and physical performance in patients on MHD. Methods: This multicenter cross-sectional study was conducted between July 2020 and April 2021 in seven hemodialysis centers in Shanghai and Suzhou, China. The hearing assessment was performed using pure-tone average (PTA). Physical performance was assessed using the Timed Up and Go Test (TUGT), handgrip strength, and gait speed. Results: Finally, 838 adult patients (male, 516 [61.6%]; 61.2 ± 2.6 years) were enrolled. Among them, 423 (50.5%) had mild to profound HL (male, 48.6% and female, 53.4%). Patients with HL had poorer physical performance than patients without HL (p < 0.001). TUGT was positively correlated with PTA (r = 0.265, p < 0.001), while handgrip strength and gait speed were negatively correlated with PTA (r = –0.356, p < 0.001 and r = –0.342, p < 0.001, respectively). Physical performance in patients aged <60 years showed significant dose-response relationships with HL. After adjusting for confounders, the odds ratios (95% confidence intervals) for HL across the TUGT quartiles (lowest to highest) were 1.00 (reference), 1.15 (0.73–1.81), 1.69 (1.07–2.70), and 2.87 (1.69–4.88) (p for trend = 0.005). Conclusion: Lower prevalence of HL was associated with a faster TUGT and a stronger handgrip strength in patients on MHD.

Anaerobic membrane bioreactors for wastewater treatment: mechanisms, fouling control, novel configurations, and future perspectives

Jiajia Li,Jinyuan Jiang,Junchao Li,Changjun He,Yong Luo,Lihong Wei 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1

As the world focuses on reducing greenhouse gas emissions and recovering energy from sewage, technologies that can recover energy and reuse wastewater are becoming increasingly important. Anaerobic membrane bioreactor (AnMBR) technology has recently attracted attention, as it can achieve energy recovery and yields high-quality effluent. However, the large-scale commercial application of AnMBRs requires that certain barriers be overcome, including membrane pollution and dissolved methane recovery. In this review article, we summarize the basic principles of anaerobic wastewater digestion and discuss the excellent performance of AnMBRs for wastewater treatment. Various factors, membrane types, and pollution are discussed, and control strategies for dealing with membrane pollution are put forward. In addition, a variety of new AnMBRs are described that may better control membrane pollution. Finally, future research directions for AnMBRs are presented to promote the large-scale integrated application of AnMBRs for industrial wastewater treatment.