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Ifosfamide-containing Regimens for Treating Patients with Osteosarcomas
Li, Yan-Yan,Jiang, Xiao-Ming,Dong, Yi-Guo,Xu, Gang,Ma, Yu-Bo Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: This systemic analysis was conducted to evaluate the efficacy and safety of an ifosfamide-containing regimen in treating patients with osteosarcoma. Methods: Clinical studies evaluating the efficacy and safety of Ifosfamide-containing regimen on response and safety for patients with osteosarcoma were identified by using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. Results: When ifosfamide-containing regimens were evaluated, 4 clinical studies which including 134 patients with osteosarcoma were considered eligible for inclusion. Systemic analysis suggested that, in all patients, pooled RR was 44.8% (60/134) in ifosfamide-containing regimens. Major adverse effects were neutropenia, leukopenia, and fatigue inIfosfamide-containing regimens; No treatment related death occurred in cantharidin combined regimens. Conclusion: This systemic analysis suggests that ifosfamide-containing regimens are associated with good response rate and acceptable toxicity in treating patients with osteosarcoma, but this result should be confirmed by randomized clinical trials.
Li Yanyan,Kwok Ron Chi-Wai,Zhang Shanshan,Gao Shanxing 기술경영경제학회 2020 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.28 No.1
Based on the knowledge-based view, this paper examines how firms can achieve an enhanced new product performance from the absorptive capacity under technological turbulence. By examining 165 Chinese pharmaceutical firms' data, this paper found that under technological turbulence, the benefits of absorptive capacity on new product performance will decrease; however, if firms maintain complementary managerial mechanisms (technological environmental scanning mechanism and coordination mechanism in this paper), the decrease effect of technological turbulence could be mitigated. Theoretically, the negative moderating effect of technological turbulence extends the investigation of the under assumptions of absorptive capacity and enriches the research on the contingency context of ACAP. Moreover, the examination of the alleviation effect regarding the managerial mechanisms responds to the scholar's appeals for more research focusing on management factors in absorptive capacity and product development research. The results also highlight the managerial-environment fit in the new product development area. Practically, this paper offers managerial implications for managers: they should focus more attention on technological breakthroughs so as to prepare early for any potential uncertainties and opportunities; moreover, managers could cultivate the managerial mechanisms to enhance knowledge monitoring and sharing activities, which could be utilised to buffer the uncertainty and update the firm's ACAP.