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Zhang, Yan-Li,Li, Qing,Yang, Xiao-Mei,Fang, Fang,Li, Jun,Wang, Ya-Hui,Yang, Qin,Zhu, Lei,Nie, Hui-Zhen,Zhang, Xue-Li,Feng, Ming-Xuan,Jiang, Shu-Heng,Tian, Guang-Ang,Hu, Li-Peng,Lee, Ho-Young,Lee, Su-J American Association for Cancer Research 2018 Cancer research Vol.78 No.9
<P>Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P>Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and the immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes and initiating immune responses. Recent studies have shown that SPON2 has complicated roles in cell migration and tumor progression. Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. SPON2-α4β1 integrin signaling activated RhoA and Rac1, increased F-actin reorganization, and promoted M1-like macrophage recruitment. F-Actin accumulation also activated the Hippo pathway by suppressing LATS1 phosphorylation, promoting YAP nuclear translocation, and initiating downstream gene expression. However, SPON2-α5β1 integrin signaling inactivated RhoA and prevented F-actin assembly, thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In HCC patients, SPON2 levels correlated positively with prognosis. Overall, our findings provide evidence that SPON2 is a critical factor in mediating the immune response against tumor cell growth and migration in HCC.</P><P><B>Significance:</B> Matricellular protein SPON2 acts as an HCC suppressor and utilizes distinct signaling events to perform dual functions in HCC microenvironment.</P><P><B>Graphical Abstract:</B> http://cancerres.aacrjournals.org/content/canres/78/9/2305/F1.large.jpg. <I>Cancer Res; 78(9); 2305–17. ©2018 AACR</I>.</P><P><B>Graphical Abstract</B></P><P> [Figure]</P>
Dengfeng Yang,Li’ang Cao,Yang Liu,Zhilian Zhang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10
Based on the analysis of the plateau performance for a 6 cylinder 8.6 L turbocharged diesel engine, a novel gas turbocharging system (GTS) is proposed to recover the engine power at high altitudes. Besides, a rolling-reflux combustor is designed to meet the structural requirements of GTS as well as to reduce the flow loss. Both the structure of the rolling-reflux combustor and the cycle thermal calculation of the GTS were described in detail in present work. The performance changes and the fuel consumption rate with engine speed at different altitudes of the GTS are compared to the original engine. Results show that when the altitude changes from 3 km to 5 km, the torque and power of the diesel engine with GTS can be recovered to that at sea level. Then, the particle image velocimetry (PIV) test is performed to study the cold flow field at the cylinder head of the rolling-reflux combustor, and the flow conditions are analyzed in detail. Finally, the flow bench is built and the aerodynamic experiment is carried out to verify the effectiveness of GTS.
Dengfeng Yang,Li’ang Cao,Ce Yang,Dazhong Lao,Harold Sun 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.6
In this work, the influence of thickness and solidity of guide vane on the unsteady flow of a radial inflow turbine with variable nozzle has been numerically studied. Three vanes with the thickness changes from 0.3 to 0.1 and the solidity changes from 1.43 to 2.86, were chosen for this study. By investigating the unsteady flow field, it is found that the vane with low thickness and high solidity (vane B) can reduce shock by 75 % compared to the vane with high thickness and low solidity (base model); meanwhile, it can also mitigate the nozzle endwall leakage flow thus improves the flow uniformity of rotor inlet. As the intensity of shock and nozzle leakage flow were mitigated, the aerodynamic loading fluctuation of rotor blade can be weakened effectively, which will lead to improved rotor blades forced response. However, at small opening, vane B shows about 0.5 % lower efficiency than the base model; at large open condition, the efficiency degradation of vane B is up to 1.4 %. Therefore, there is a trade-off between the efficiency and forced response when choosing the nozzle vane solidity and thickness.
Brigatinib versus Crizotinib in <i>ALK</i>-Positive Non-Small-Cell Lung Cancer
Camidge, D. Ross,Kim, Hye Ryun,Ahn, Myung-Ju,Yang, James Chih-Hsin,Han, Ji-Youn,Lee, Jong-Seok,Hochmair, Maximilian J.,Li, Jacky Yu-Chung,Chang, Gee-Chen,Lee, Ki Hyeong,Gridelli, Cesare,Delmonte, Ange New England Journal of Medicine 2018 The New England journal of medicine Vol.379 No.21
Hai-Zhong Yu,Yan Ma,Shang-zhi Zhang,Dong-qiong Fei,Bing Liu,Li-ang Yang,Azharuddin Muhammad,Ming-hui Liu,Jia-Ping Xu 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1
1-Deoxynojirimycin (DNJ) as a kind of alkaloid has been confirmed that could modulate glycometabolism andhas toxicity for the eri-silkworm in our previous research. On the contrary, what is the potentially defensivemechanism when the DNJ enters the eri-silkworm. Based on comparative transcriptome sequencing, we foundthat ATP-binding cassette (ABC) transporter genes could be induced significantly by DNJ. In this study, a total of16 putative ABC transporter genes were identified, which can be classified into seven subfamilies, namely oneABCA, four ABCBs, three ABCCs, two ABCDs, one ABCE, three ABCFs, and two ABCGs. Phylogenetic analysisrevealed that ScABCs had strong conservation with Bombyx mori. Reverse transcription quantitative PCR (RTqPCR)suggested that 6 ABC transporters had a strong positive correlation between RT-qPCR and transcriptomedata. Additionally, S. c. ricini ABC transporter C-subfamily 4 (ScABCC4), S. c. ricini ABC transporter G-subfamily4 (ScABCG4), S. c. ricini ABC transporter A-subfamily 3 (ScABCA3) and S. c. ricini ABC transporter C-subfamily10 (ScABCC10) showed different expression pattern in two feed dose (1% and 2% DNJ) and three time points(6h, 12 h, 48 h). This study provides the first study on identification, characterization and expression patterns ofABC transporter genes in S. c. ricini response to DNJ, and lays a foundation for further understanding of theirphysiological roles response to the alkaloid.