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RISS 인기검색어
- 검색키워드
- 저자 : Lahann, Joerg (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Multimodal delivery of irinotecan from microparticles with two distinct compartments
Rahmani, Sahar,Park, Tae-Hong,Dishman, Acacia Frances,Lahann, Joerg Elsevier 2013 Journal of controlled release Vol.172 No.1
<P><B>Abstract</B></P> <P>In the last several decades, research in the field of drug delivery has been challenged with the fabrication of carrier systems engineered to deliver therapeutics to the target site with sustained and controlled release kinetics. Herein, we report the fabrication of microparticles composed of two distinct compartments: i) one compartment containing a pH responsive polymer, acetal-modified dextran, and PLGA (polylactide-<I>co</I>-glycolide), and ii) one compartment composed entirely of PLGA. We demonstrate the complete release of dextran from the microparticles during a 10-hour period in an acidic pH environment and the complete degradation of one compartment in less than 24h. This is in congruence with the stability of the same microparticles in neutral pH over the 24-hour period. Such microparticles can be used as pH responsive carrier systems for drug delivery applications where their cargo will only be released when the optimum pH window is reached. The feasibility of the microparticle system for such an application was confirmed by encapsulating a cancer therapeutic, irinotecan, in the compartment containing the acetal-modified dextran polymer and the pH dependent release over a 5-day period was studied. It was found that upon pH change to an acidic environment, over 50% of the drug was first released at a rapid rate for 10h, similar to that observed for the dextran release, before continuing at a more controlled rate for 4days. As such, these microparticles can play an important role in the fabrication of novel drug delivery systems due to the selective, controlled, and pH responsive release of their encapsulated therapeutics.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Anisotropic hybrid particles based on electrohydrodynamic co-jetting of nanoparticle suspensions
Hwang, Sangyeul,Roh, Kyung-Ho,Lim, Dong Woo,Wang, Guoyu,Uher, Ctirad,Lahann, Joerg Royal Society of Chemistry 2010 Physical chemistry chemical physics Vol.12 No.38
<P>Electrohydrodynamic co-jetting of two different nanocrystal suspensions can result in anisotropic nanocomposite particles. Using this approach, we are able to prepare submicron-sized, spherical Janus particles (464 ± 242 nm), which are not only comprised of two chemically distinct compartments, but are also morphologically anisotropic. Specifically, multifunctional hybrid particles have been derived, which are composed of a crosslinked copolymer, poly(acrylamide-<I>co</I>-acrylic acid) (p(AAm-<I>co</I>-AA)), and compartmentalized with respect to two metal oxides, <I>i.e.</I> titanium dioxide (TiO<SUB>2</SUB>) and magnetite (Fe<SUB>3</SUB>O<SUB>4</SUB>). Due to size as well as optical color differences between the Fe<SUB>3</SUB>O<SUB>4</SUB> (∼10 nm) and TiO<SUB>2</SUB> (<100 nm) loadings, the surface morphology of the two compartments are significantly different and the particles display magnetic, optical, and interfacial anisotropy. Magnetic anisotropy of the particles has been utilized to control the particles' positioning in an external magnetic field, which—with further work—may lead to magnetically switchable surfaces for display applications.</P> <P>Graphic Abstract</P><P>Polymeric Janus particles with distinguishable surface morphology and magneto-optical properties are prepared by electrohydrodynamic co-jetting of Fe<SUB>3</SUB>O<SUB>4</SUB> and TiO<SUB>2</SUB> suspensions. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cp00264j'> </P>
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Kwon, M.,Jordahl, J.,Phillips, A.,Chung, K.,Lee, S.,Gierschner, J.,Lahann, J.,Kim, J. THE ROYAL SOCIETY OF CHEMISTRY 2016 Chemical Science Vol.7 No.3
<P>Metal-free organic phosphors can be an attractive smart optical sensing materials since, in such compounds, intersystem crossing (ISC) and the phosphorescence process are placed in subtle competition with fluorescence, internal conversion (IC), and non-radiative decay pathways. Here, we report a unique environment-dependent multi-luminescence switching behavior of metal-free organic phosphorescent materials. Through combined photophysical measurements and computational electronic structure analysis, we systematically investigated how physicochemical properties of organic solvents affect the photophysical pathways of the metal-free organic phosphors. By rationally adapting the finding into phosphor-doped electrospun polymer fibers, we developed a new luminometric sensory platform and achieved selective detection of eight different common organic solvents. The presented finding provides new possibilities for metal-free organic phosphors to be a novel class of smart optical sensory materials.</P>
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Janus-Core and Shell Microfibers
Lee, Kyung Jin,Park, Tae-Hong,Hwang, Sangyeul,Yoon, Jaewon,Lahann, Joerg American Chemical Society 2013 Langmuir Vol.29 No.20
<P>Janus microcylinders composed of different polymers were prepared through coaxial co-jetting with dual-core flows, followed by cross-linking, microsectioning, and shell removal. Uniquely shaped building blocks can be fabricated by photo-patterning of one hemisphere of the microcylinders.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2013/langd5.2013.29.issue-20/la4009416/production/images/medium/la-2013-009416_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la4009416'>ACS Electronic Supporting Info</A></P>
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