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Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery
Nam, Keonwook,Kim, Taehyung,Kim, Young Min,Yang, Kyungjik,Choe, Deokyoung,Mensah, Lawrence B.,Choi, Ki Young,Roh, Young Hoon The Royal Society of Chemistry 2019 Chemical communications Vol.55 No.34
<P>We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery <I>via</I> sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.</P>