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Kyoungcheol CHOI,Hongbin KIM,Chan Hee LEE,Kwang Suk LIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Gene therapy is one of the biopharmaceuticals that can treat diabetes, cancer, rheumatism, and incurable diseases by delivering genes such as therapeutic DNA and RNA. To enhance intracellular uptake of nucleotide, nonviral gene carrier was developed using cationic polymers, reducible polymers and peptides. However, the use of nonviral systems as a gene carrier still requires improvement of toxicity and efficiency. Cellulose nanocrystals(CNC) have good biocompatibility and excellent physical properties and are being used in various fields including biomaterials, tissue engineering, and drug delivery. In the previous study, we demonstrated characteristics, efficiency and applications of Zinc/DNA nanocluster. Thus, we utilized the Zn/DNA nanocluster system to develop a gene delivery system using CNC. In this study, a nano self-assembled therapeutic gene delivery system was developed using CNC and ZD nanocluster. The formation of the CNC/Zn/DNA complex using metallothionein(MT) and heat shock protein 27(HSP27) expression vector was optimized, and its transfection efficiency was confirmed. It was also verified the protective effect of CNC/Zn/MT and CNC/ Zn/HSP27 complex in the cells exposed oxidative stress after transfection. It may be expected to be a useful gene delivery system for the delivery of therapeutic genes.
항암제 개발: 토포아이소머라제, HSP90, mTOR 및 티로신키나제 억제제
최경철(Kyoungcheol Choi),이성호(Seongho Lee),권미지(Miji Kwon),홍세영(Seyoung Hong),박희호(Hee Ho Park),임광석(Kwang Suk Lim) 한국생물공학회 2021 KSBB Journal Vol.36 No.2
Chemical anticancer drugs that have been used for a long time for the treatment of cancer have high anticancer effects and many side effects. The side effects of anticancer drugs have also affected normal cells because they induce the death of cancer cells by inhibiting or blocking essential mechanisms for cell survival. Recently, inhibitory drugs that inhibit specific mechanisms of cancer cells are receiving a lot of attention as anticancer drugs. Inhibitory drugs have less effect on normal cells by inhibiting the activity of target proteins that are overexpressed in cancer cells. Representative anticancer inhibitors among many inhibitory drugs are mTOR inhibitors, topoisomerase inhibitors, heat shock protein 90 (HSP90) inhibitors and tyrosine kinase inhibitors. For each of these inhibitor family, new candidate inhibitor drugs are continuously being developed and clinical trials are underway. In this review, we will examine the drug mechanism of each inhibitor drug, and describe the approved drugs and drugs in clinical trials.
병렬형 하이브리드 전기자동차의 엔진/모터/배터리 용량 및 운전전략 최적화
오경철(Kyoungcheol Oh),최동훈(Donghun Choi),김현수(Hyunsoo Kim) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The core technology of hybrid electric vehicle is to reduce fuel consumption and emissions. In order to analyze the HEV performance, it is carried out mathematical modeling of the HEV powertrains and development of the HEV performance simulator. This paper presents optimum power distribution ratio between the engine and the motor is obtained which minimizes the objective function by the penalty function method. An objective function is suggested, which consists of total engine fuel consumption and total electric energy. It is found from the optimization results that the optimal power distribution ratio can be obtained easily compared with those by the existing trial and error design method. An optimization process is proposed to determine the engine/motor/battery size to obtain the minimum fuel consumption while satisfying vehicle acceleration performance and an optimization process of HEV control strategy using the results determined in the first optimization process.
Electromechanical properties of CNT-coated cotton yarn for electronic textile applications
Kang, Tae June,Choi, Ajeong,Kim, Dai-Hong,Jin, Kyoungcheol,Seo, Dong Kyun,Jeong, Dae Hong,Hong, Seong-Hyeon,Park, Yung Woo,Kim, Yong Hyup Institute of Physics Publishing 2011 Smart materials & structures Vol.20 No.1
<P>Smart fabrics have attracted considerable attention due to their potential applications. The essential features of smart fabrics include wearability, weaveability, and stretchability, as well as their sensing/response capability, which is frequently based on electrical measurement. Thus, the electromechanical behavior of these fabrics is considered the most important material property. Here, we report the negative piezoresistance of single-walled carbon nanotube coated cotton yarn (SWNT-CY). The gauge factor (the ratio of the normalized change in piezoresistance to the change in strain) of SWNT-CY is measured to be − 24. It is noteworthy that the factor is negative and an order of magnitude higher than that for conventional metal strain gauges. The negative piezoresistance is due to mechanical contact between fabric fibers, which leads to better electrical paths of SWNT networks. The conduction behavior can be modeled as fluctuation-induced tunneling (FIT) through the contact barriers between conducting regions. The effective barrier strength of strained SWNT-CY is measured to be ∼ 30% lower than that of unstrained SWNT-CY. This characteristic may offer new design opportunities for wearable electronics and has significant implications for sensor applications. </P>