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Ika Komala,Erwin Soeriadi,Astri Astuti,Achmad Hussein Kartamihardja 아시아심장혈관영상의학회 2024 Cardiovascular Imaging Asia Vol.8 No.2
Objective: A nitrate-augmented 99mTc-sestamibi cardiac single-photon emission computed tomography imaging protocol has been shown to improve detection of viable cardiac segments. This protocol usually makes use of a short-acting nitrate and requires patients to stop prescribed long-acting nitrate medication for at least two days prior to the study. No previous studies have used long-acting nitrate in myocardial viability research. Materials and Methods: Ten adult patients who had routinely used long-acting nitrate medication participated in this nitrate-augmented myocardial viability study. A long-acting nitrate was given one hour prior to 99mTc-sestamibi injection, and results were evaluated based on uptake changes after nitrate augmentation. Myocardial reversibility was assessed using visual scoring with a 17-segment model, with increased uptake ≥10% considered viable. Results: Eight of 10 patients had a greater than 10% increase in uptake compared to baseline, and nine of 10 patients showed significant changes in sum rest score (SRS) and sum rest nitrate score (SRNS) p<0.001. In most patients, blood pressure dropped significantly after nitrate administration. One patient with no uptake changes or myocardial reversibility based on SRS and SRNS demonstrated increased blood pressure after nitrate administration. Conclusion: Oral long-acting nitrates are a feasible option for nitrate-augmented myocardial viability studies. Patients on long-acting nitrate therapy who require myocardial viability study do not need to discontinue the medication prior to the study. Further evaluations with larger samples are needed to confirm these findings.
Arun Kumar, B.R.,Komala, R International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.4
In the recent past enormous enterprise applications have migrated into the cloud computing (CC). The researchers have contributed to this ever growing technology and as a result several innovations strengthened to offer the quality of service (QoS) as per the demand of the customer. It was treated that management of resources as the major challenge to offer the QoS while focusing on the trade-offs among the performance, availability, reliability and the cost. Apart from these regular key focuses to meet the QoS other key issues in CC are data integrity, privacy, transparency, security and legal aspects (DIPTSL). This paper aims to carry out the literature survey by reflecting on the prior art of the work with regard to QoS in CC and possible implementation of block chain to implement decentralised CC solutions governing DIPTSL as an integral part of QoS.
Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
Arun Prakash Mishra,Archana B. Siva,Chandrashekaran Gurunathan,Y. Komala,B. Jyothi Lakshmi 한국실험동물학회 2020 Laboratory Animal Research Vol.36 No.4
WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity. Previously, we have reported that the absence of WDR13 in diabetic Leprdb/db mice helps in amelioration of fatty liver phenotype along with diabetes and systemic inflammation. This intrigued us to study direct liver injury and hepatic regeneration in Wdr13−/0 mice using hepatotoxin CCl4. In the present study we report slower hepatic regeneration in Wdr13−/0 mice as compared to their wild type littermates after CCl4 administration. Interestingly, during the regeneration phase, hepatic hypertriglyceridemia was observed in Wdr13−/0 mice. Further analyses revealed an upregulation of PPAR pathway in the liver of CCl4- administered Wdr13−/0 mice, causing de novo lipogenesis. The slower hepatic regeneration observed in CCl4 administered Wdr13−/0 mice, may be linked to liver hypertriglyceridemia because of activation of PPAR pathway.
Daman SUDARMAN,Dwi KARTINI,R Arief HELMI,Rita Komala DEWI 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.6
RTD tea, which is the most popular soft drink choice after bottled water, has experienced trade challenges during the COVID-19 pandemic. The purpose of this study was to examine the effect of managerial capabilities, strategic alliance and strategic innovation on product lifecycle management and corporate performance is moderated by the social media in RTD tea companies. The research method used in this research is a quantitative approach with data processing using SemPls. The results showed that the Managerial Capabilities variable did not have a significant effect on Marketing Performance, the Managerial Capabilities variable did not have a significant effect on Product Lifecycle Management, the Product Lifecycle Management variable had a significant effect on Marketing Performance, the Social Media variable was proven to mediate PLM Marketing Performance, the Strategic Alliance variable did not have a significant effect on Marketing Performance. The Strategic Alliance variable had no significant effect on Product Lifecycle Management, the Strategic Innovation variable had a significant effect on Marketing Performance, and the Strategic Innovation variable had a significant effect on Product Lifecycle Management.