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Takeshige, Nobuyuki,Yin, Guang,Ohnaka, Keizo,Kono, Suminori,Ueki, Takashi,Tanaka, Masao,Maehara, Yoshihiko,Okamura, Takeshi,Ikejiri, Koji,Maekawa, Takafumi,Yasunami, Yohichi,Takenaka, Kenji,Ichimiya, Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. In a study of 685 cases of colorectal cancer and 778 community controls in Japan, we examined the associations of the FokI, BsmI, ApaI, and TaqI polymorphisms with colorectal cancer risk and effect modification by dietary calcium and vitamin D. Genotypes were determined by the PCR-RFLP method. The ApaI polymorphism seemed to be associated with a decreased risk of colorectal cancer, particularly of rectal cancer. The adjusted odds ratio of colorectal cancer for the ApaI AA and Aa genotypes combined versus the aa genotype was 0.83 (95% confidence interval [CI] 0.67-1.02), and the corresponding value for rectal cancer was 0.75 (95%CI 0.56-0.99). A decreased risk of colorectal cancer for the ApaI AA and Aa genotypes combined was more evident in individuals with high calcium intake (interaction p=0.055). The FokI polymorphism seemed to be associated with a decreased risk of colon cancer among those with high vitamin D intake (interaction p=0.09). The BsmI and TaqI polymorphisms were unrelated to colorectal cancer risk, and the null associations were not modified by calcium or vitamin D intake. In conclusion, the ApaI polymorphism may be associated with a decreased risk of colorectal cancer in Japanese, dependent on dietary calcium intake.
Morita, Makiko,Yin, Guang,Yoshimitsu, Shin-Ichiro,Ohnaka, Keizo,Toyomura, Kengo,Kono, Suminori,Ueki, Takashi,Tanaka, Masao,Kakeji, Yoshihiro,Maehara, Yoshihiko,Okamura, Takeshi,Ikejiri, Koji,Futami, K Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.
Perforated Early Gastric Cancer: Uncommon and Easily Missed a Case Report and Review of Literature
Lim, Raymond Hon Giat,Tay, Clifton Ming,Wong, Benjamin,Chong, Choon Seng,Kono, Koji,So, Jimmy Bok Yan,Shabbir, Asim The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.1
Gastric carcinoma rarely presents as a perforation, but when it does, is perceived as advanced disease. The majority of such perforations are Stage III/IV disease. A T1 gastric carcinoma has never been reported to perforate spontaneously in English literature. We present a 56 year-old Chinese male who presented with a perforated gastric ulcer. Intra-operatively, there was no suspicion of malignancy. At operation, an open omental patch repair was performed. Post-operative endoscopy revealed a macroscopic Type 0~III tumour and from the ulcer edge biopsy was reported as adenocarcinoma. Subsequently, the patient underwent open subtotal gastrectomy and formal D2 lymphadenectomy. The final histopathology report confirms T1b N0 disease. The occurrence of a perforated early gastric cancer reemphasises the need for vigilance, including intra-operative frozen section and/or biopsy, as well as routine post-operative endoscopy for all patients.
Tetsuya Kojima,Toshihiko Takauchi,Toshifumi Ise,Isao Iyoda,Hiroyuki Sasao,Yoshiyuki Kono,Koji Temma,Nobuyoshi Inoue,Akira Kawamoto 전력전자학회 2004 ICPE(ISPE)논문집 Vol.- No.-
A new parallel type voltage sag compensator is proposed. The proposed system can reduce the necessary capacity of a storage capacitor for voltage sag compensation by boost type power factor correction rectifier getting charging energy from residual voltage of utilities as it compensates the load voltage. This paper shows principle and control system of the proposed circuit. Compensation<br/> performances are demonstrated by experiments.
Perforated Early Gastric Cancer: Uncommon and Easily Missed a Case Report and Review of Literature
Raymond Hon Giat Lim,Asim Shabbir,Clifton Ming Tay,Benjamin Wong,Choon Seng Chong,Koji Kono,Jimmy Bok Yan So 대한위암학회 2013 Journal of gastric cancer Vol.13 No.1
Gastric carcinoma rarely presents as a perforation, but when it does, is perceived as advanced disease. The majority of such perforations are Stage III/IV disease. A T1 gastric carcinoma has never been reported to perforate spontaneously in English literature. We present a 56 year-old Chinese male who presented with a perforated gastric ulcer. Intra-operatively, there was no suspicion of malignancy. At operation, an open omental patch repair was performed. Post-operative endoscopy revealed a macroscopic Type 0~III tumour and from the ulcer edge biopsy was reported as adenocarcinoma. Subsequently, the patient underwent open subtotal gastrectomy and formal D2 lymphadenectomy. The final histopathology report confirms T1b N0 disease. The occurrence of a perforated early gastric cancer reemphasises the need for vigilance, including intra-operative frozen section and/or biopsy, as well as routine post-operative endoscopy for all patients.