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      • KCI등재

        폐경여성에서의 내시경하 수술의 적응증

        우이키나 ( Kina Uy ),김태희 ( Tae Hee Kim ),이해혁 ( Hae Hyeog Lee ),정수호 ( Soo Ho Chung ),이병익 ( Byoung Ick Lee ) 대한폐경학회 2010 대한폐경학회지 Vol.16 No.1

        연구목적: 폐경여성에서 자궁 내시경 수술의 적응증을 알아보고자 한다. 연구재료 및 방법: 2001년 3월부터 2009년 3월까지 순천향대학교 부천병원에서 내시경수술을 시행한 시행한 43명을 중심으로 후향적으로 환자의 임상적 특징, 검사결과, 수술 후에 합병증과 결과에 대해서 조사하였다. 결과: 내시경 수술을 통해서 내막조직검사 26명, 내막용종제거술 8명, 자궁근종제거술 7명, 비정상 자궁출혈과 자궁내막증식증 치료 1명, 자궁내종괴 1명, 자궁근종의 평균 크기는 3.2 cm, 재원기간은 평균 2일, 수술 후에 빈혈 수치는 1.1 g/dl이고, 평균 수술 시간은 36분이었다. 결론: 자궁내시경 수술의 적응증은 광범위하게 변화하고 있으며 순수한 자궁내근종, 자궁내막 하 근종, 자궁내막용 중, 자궁선근종, 자궁내막증식증, 물묵자궁증, 비정상자궁출혈이 내시경하 수술로 치료될 수 있다. 자궁내시경수술 시복부초음파가 수술시의 합병증을 줄인다. Objectives: To evaluate the spectrum of hysteroscopic surgery to be extended. Methods: Forty-three women who underwent hysteroscopic procedures with Urione(R) solution or normal saline as distension media between March 2001 and March 2009 were randomized. The clinical characteristics, laboratory data, and post-operative results were retrospectively analyzed. Results: The following hysteroscopic procedures were performed: endometrial biopsy, 26; endometrial polypectomy, 8; myomectomy, 7; ablation for dysfunctional uterine bleeding and endometrial hyperplasia, 1; and excision of an endometrial mass, 1. The mean size of the myomas was 3.2 cm. The average duration of hospitalization was 2 days. The average change in hemoglobin was 1.1 g/dl. The mean operative time was 36 minutes. Conclusion: The indications for hysteroscopic procedures can be extended. Pure intramural myomas, submucosal myomas, endometrial polyps, adenomyosis, endometrial hyperplasia, hydrometra, and abnormal uterine bleeding can be treated via a hysteroscope. Intra-operative transabdominal ultrasonographic guidance can be helpful during hysteroscopic procedures, and reduces the complication and morbidity rates. (J Korean Soc Menopause 2010;16:46-51)

      • KCI등재

        Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory

        유기서,Kina Lee,이용석,Won-Jong Oh,Hyong Kyu Kim 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.5

        Guanine nucleotide exchange factors (GEFs) play multiple functional roles in neurons. In a previous study, we reported that Arhgef4 (Rho guanine nucleotide exchange factor 4) functioned as a negative regulator of the excitatory synaptic function by sequestering postsynaptic density protein 95 (PSD-95). However, the role of Arhgef4 in behavior has not been examined. We performed comprehensive behavioral tests in knockout (KO) mice to investigate of the effects of Arhgef4 deficiency. We found that the expressed PSD-95 particle size was significantly increased in hippocampal neuronal cultures from Arhgef4 KO mice, which is consistent with the previous in vitro findings. Arhgef4 KO mice exhibited general motor activity and anxiety-like behavior comparable to those of the wild type littermates. However, spatial memory and object recognition memory were significantly enhanced in the Arhgef4 KO mice. Taken together, these data confirm the role of Arhgef4 as a negative synaptic regulator at the behavioral level.

      • KCI등재

        The Effects of Group Cognitive Behavioral Therapy on the Improvement of Depression and Anxiety in Adolescents with Problematic Internet Use

        Sang-Hyun Kim,Hyeon-Woo Yim,Sun-Jin Jo,Kyu-In Jung,Kina Lee,Min-Hyeon Park 대한소아청소년정신의학회 2018 소아청소년정신의학 Vol.29 No.2

        Objectives: The overuse of the Internet among adolescents has increased dramatically in recent years, leading to pathological or problematic Internet use. Cognitive behavioral therapy (CBT) is known to be effective for the treatment of problematic Internet use, particularly for adolescents. The aim of the present study was to evaluate the therapeutic efficacy of group CBT for problematic Internet use in adolescents. Methods: A total of 17 patients aged 12–17 years who met Young’s diagnostic questionnaire criteria of problematic Internet use participated in a school-based eight-session group CBT program. The level of problematic Internet use among participating students was measured using Young’s Internet Addiction Scale (IAS). Depression and anxiety levels were evaluated using the Children’s Depression Inventory (CDI) and the State-Trait Anxiety Inventory (STAI), respectively. Each construct was assessed at baseline, immediately after the intervention, and at a one-month follow-up visit. Statistical significance was based on a p-value of <0.05. Results: Immediately after the program, the IAS, CDI, and State Anxiety Inventory (SAI) scores were significantly lower than before the program. At the one-month follow-up assessment, the IAS scores remained low, and the CDI and SAI scores were even lower than immediately after the program. Conclusion: Group CBT was effective for adolescents with problematic Internet use, and was also demonstrated to improve depression and anxiety.

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