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Seong-Min Kim,Singeun Kim,Woo Jin Lee,Kyung-Mi Kim,Jae-Chul Jung 건강기능식품미래포럼 2023 건강기능식품미래포럼 학술지 Vol.3 No.4
Styphnolobium japonicum belongs to the Fabaceae family. This plant, particularly its fruit, is widely used in traditional medicine to treat various disorders. Lately, there has been an increased interest in using the salt-out approach for extracting active substances from plants, leading to improved yields. The purpose of this study was to prepare an extract from the S. japonicum fruit using the salt-out method (SJFSOE) and explore its benefits by examining its effects on the secretion of nitic oxide (NO) from lipopolysaccharide (LPS)-treated Raw264.7 cells (murine macrophage cells) and release of matrix metalloproteases (MMPs) from ultraviolet B (UVB)-irradiated CCD-986sk cells (normal human skin fibroblast cells). Our findings show that SJFSOE contains mainly sophoricoside (877.3 mg/g of the extract), that is over twenty times that obtained by a method using ethanol, and significantly suppressed both LPS-induced secretion of NO and UVB-stimulated release of the pro-MMP-1 and MMP-2 from the respective cells. The results imply that SJFSOE has the potential to offer benefits, especially in conditions characterized by inflammation.
Study on Toxicity of Cornus alba L. Extract in Sprague Dawley Rats
Ki Cheon Kim,Jeong Tae-Bin,Kim Singeun,Kim Kyung-Mi,Choi Minjun,Jung Jae-Chul,이민원,Jeong Pan-Young 건강기능식품미래포럼 2021 건강기능식품미래포럼 학술지 Vol.1 No.4
The leaves and stalk of Cornus alba L. have been known to have anti-inflammatory, anticoagulating and diuretic actions according to Korean traditional medical encyclopedia. Thus, this plant could be a useful candidate as a material for health functional foods and medicines. However, the safety should be ensured before it is developed as a product to be used for health. In the present study, the ethanol extract of leaves and stalk (extract of C. alba L. [ECA]) was prepared and tested for acute/subacute and gene toxicities according to the guidelines provided by Organization for Economic Cooperation and Development (OECD). Also, we detected some antioxidants that can be used as indicator molecules and antioxidant activities by measuring the ability of scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. Chlorogenic acid, gallic acid and quercetin chosen as indicator molecules were clearly detected by high-performance liquid chromatography (HPLC) and quantified by peak areas in HPLC chromatograms, which were 2.2 ± 0.5 mg/g (chlorogenic acid), 6.4 ± 0.8 mg/g (gallic acid) and 3.2 ± 0.4 mg/g (quercetin), respectively. ECA was also shown to scavenge DPPH radicals with the activity comparable to that of ascorbate. On the other hand, ECA even at dose of 5,000 mg/kg did not show any particular responses and symptoms in hematology, blood chemistry and histology of liver and kidney. Death was not observed either. ECA showed negative results in the tests of reverse mutation, chromosomal aberration and micronucleus, indicating it has no genotoxicities. These results suggest that C. alba L. is a safe material that can be used as a health functional foods.
Seong-Min Kim,Singeun Kim,Woo Jin Lee,Kyung-Mi Kim,Jae-Chul Jung 건강기능식품미래포럼 2023 건강기능식품미래포럼 학술지 Vol.3 No.4
The fruit of Styphnolobium japonicum L. also known as the scholar tree, has been studied for its benefits in addressing various diseases since it was shown to contain a variety of bioactive compounds. However, there has not been any investigation into its effect on photo-aging. Thus, we prepared the extract of S. japonicum fruit through a salt-out method (SJFSOE) since this method was known to demonstrate a high efficiency in extracting active ingredients from plants and evaluated the effect of SJFSOE on photo-aging induced on dorsal skin of the hairless mice by ultraviolet B (UVB) radiation (0.18 J/cm2, three times a week for 15 weeks). We found that UVB irradiation induced severe skin damages that were evidenced by significantly increased oxidative stress, inflammatory reaction, apoptosis of keratocytes, expression of genes of matrix metalloproteinases (MMPs) and NADPH oxidase 2 (Nox2), and wrinkle formation (P < 0.001). However, all these detrimental reactions were significantly reduced in the mice treated with oral administration of SJFSOE (200 mg/kg/day for 15 week) (P < 0.001). In contrast to the genes of MMPs and Nox2, the expressions of the genes of hyaluronic acid synthase (Has) 1, Has2, Has3, and collagen (COL) 1A1, COL1A2 were not affected by UVB irradiation but enhanced significantly in the mice treated with both UVB and SJFSOE. L-ascorbic acid (100 mg/kg/day for 15 weeks) showed the beneficial effects like SJFSOE. These results suggest that SJFSOE has the potential as an anti-photo-aging agent by preventing and repairing the damages induced by UV through its antioxidant activity.
Toxicity Evaluation by Single and Repeated Administration of Yeast Hydrolysate DNF-10
Yejin Ahn,Singeun Kim,Hyung Joo Suh,Eun Young Jung 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.1
This study aimed at investigating the acute and subacute oral toxicity of yeast hydrolysate (DNF-10) in Sprague-Dawley rats. To determine the acute toxicity of DNF-10, it was orally administered to rats at a dose of 5,000 mg/kg. Furthermore, to determine subacute toxicity of DNF-10, it was orally administered to female and male rats at a dose of 1,000 mg/kg for 90 days. In the acute toxicity test, the experimental group did not show changes in body and organ weights compared to the corresponding weights in the control group. When compared to female controls, the DNF-10- treated female rats showed decreased red blood cell counts, haemoglobin, and total bilirubin levels; however, the parameters remained within the normal range. In the subacute toxicity test, DNF-10 administration significantly reduced body weight among male rats, which appears attributable to the anti-obesity effect of the compound. In the experimental groups, significant differences in some haematological parameters were considered as non-toxic because the results were within the normal range. These results suggest that DNF-10 is safe and non-toxic at single doses (5,000 mg/kg) and repeated doses (1,000 mg/kg).
Effects of explosive puffing process on the reduction of ochratoxin A in rice and oats
Lee, Hyun Jung,Kim, Singeun,Suh, Hyung Joo,Ryu, Dojin BUTTERWORTH-HEINEMANN 2019 FOOD CONTROL Vol.95 No.-
<P><B>Abstract</B></P> <P>Ochratoxin A (OTA) represents one of the most widespread mycotoxins in agricultural commodities in the world and is considered as a possible human carcinogen with its potent nephrotoxicity. Since OTA is stable under most food processing conditions, it has been detected in a variety of cereal grains and their processed products. We investigated the effect of explosive puffing process on the reduction of OTA in rice and oats. Moisture content of rice and oat grains were adjusted to 15% (wet weight basis, wb) and OTA was spiked at 100 μg/kg. Then the grains were processed by explosive puffing at 0.5, 0.7, and 0.9 MPa. The moisture content of puffed rice and oat snacks were in the ranges of 5–8% wb and 6–10% wb, respectively, and the moisture content in the puffed products were decreased with increasing pressure. In addition, decreased bulk density and increased degree of redness (<I>a</I>) were observed with increased explosive puffing pressure. The reduction of OTA concentration in puffed rice and oats were decreased with increasing explosive puffing pressures in the ranges of 15–28% and 38–52%, respectively. These results suggest that OTA in rice and oat may be reduced significantly by explosive puffing process, which can be applied to commercial production of cereal-based snack foods.</P>