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- 저자 : Kiana Pirian (검색결과 1 건)
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Mitra Arman,Kiana Pirian,Mostafa Alinaghizadeh,Fatemeh Khosheghbal,Reza Nahavandi,Saeid Tamadoni Jahromi 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.4
Nowadays, the essential oil has received a special position for the treatment of diseases. Although Satureja rechingeri Jamzad is an endemic species of Iran, unfortunately few studies have been conducted on its biological properties. In this study, along with the analysis of the compounds of Satureja rechingeri essential oil, cytotoxic, antioxidant and antibacterial properties of the essential oil of this species were investigated. The compounds of prepared essential oil were analyzed by GC-FID and GC–MS using Clevenger. Disc diffusion and MTT methods were used to determine the antibacterial activity and cytotoxicity of the essential oil, respectively. The antioxidant activity of the essential oil was measured by two methods of reducing power assay and DPPH free radical scavenging. p-Cymene (46.5%) was the most identified compound in the essential oil. The essential oil showed higher inhibitory effect on seven bacterial strains relative to the standard antibiotics. The studied essential oil showed significant concentration-dependent inhibitory effect on four cancer cells of Vero, SW480, MCF7 and JET3 with 50% lethal effect of 15.6, 125, 15.6 and 250 μg/mL for each line, respectively. The highest adsorption (2.6 nM) was at 500 μg/mL for reducing power assay and 50% free radical inhibition at a concentration of 375 μg/mL for DPPH antioxidant assay. In general, the essential oil of Satureja rechingeri with high antioxidant, antibacterial and anticancer activity can be used as a cheap and affordable natural product in clinical and pharmaceutical fields.
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