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      • Health-Related Quality of Life of Breast Cancer Patients in iran: Pooled Analysis using Generalized Estimating Equations

        Kiadaliri, Aliasghar Ahmad,Bastani, Peivand,ibrahimipour, Hossein Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

        Objective: The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework. Methods and Materials: A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxorubicin and cyclophosphamide (FAC) or docetaxel, doxorubicin, cyclophosphamide (TAC) in south of Iran. HRQoL was assessed at baseline, end of chemotherapy and four months thereafter using the QLQ-C30 questionnaire from European Organization for Research and Treatment of Cancer (EORTC). Generalized estimating equations (GEE) was applied for statistical analysis. Results: The mean of age at baseline was $48.5{\pm}10.6$. 70% and 14% of patients were married and smokers, respectively, and 20% suffered from another disease besides breast cancer. The results of GEE showed that after control for baseline scores, the HRQoL significantly improved over time. Although, the patients in FAC group had higher scores than the TAC group, the differences also diminished over time. Smoking, marital status and having child affected some scales of HRQoL. None of other variables were significantly related to HRQoL. Conclusion: Although patients in TAC groups had lower level of HRQoL over 8 months follow up, they experienced faster improvement than the FAC group. This implies that in long-term, improvements in TAC group are higher than FAC. Having children was positively correlated with HRQoL. Generally, there were no demographic and socio-economic differences in HRQoL in these patients between the chemotherapeutic regimens.

      • Gender and Social Disparities in Esophagus Cancer Incidence in Iran, 2003-2009: A Time Trend Province-level Study

        Kiadaliri, Aliasghar Ahmad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Background: Esophagus cancer (EC) is among the five most common cancers in both sexes in Iran, with an incidence rate well above world average. Social rank (SR) of individuals and regions are well-known independent predictors of EC incidence. The aim of current study was to assess gender and social disparities in EC incidence across Iran's provinces through 2003-2009. Materials and Methods: Data on distribution of population at province level were obtained from the Statistical Centre of Iran. Age-standardized incidence rates of EC were gathered from the National Cancer Registry. The Human Development Index (HDI) was used to assess the province social rank. Rate ratios and Kunst and Mackenbach relative indices of inequality ($RII_{KM}$) were used to assess gender and social inequalities, respectively. Annual percentage change (APC) was calculated using joinpoint regression. Results: EC incidence rate increased 4.6% and 6.5% per year among females and males, respectively. There were no gender disparities in EC incidence over the study period. There were substantial social disparities in favor of better-off provinces in Iran. These social disparities were generally the same between males and females and were stable over the study period. Conclusions: The results showed an inverse association between the provinces' social rank and EC incidence rate in Iran. In addition, I found that, in contrast with international trends, women are at the same risk of EC as men in Iran. Further investigations are needed to explain these disparities in EC incidence across the provinces.

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        Social disparity in breast and ovarian cancer incidences in Iran, 2003-2009: A time trend province-level study

        Aliasghar A. Kiadaliri 한국유방암학회 2013 Journal of breast cancer Vol.16 No.4

        Purpose: This pioneering study aimed to investigate social disparitiesin breast cancer (BC) and ovarian cancer (OC) incidencerates among women across Iran’s provinces from 2003 to 2009. Methods: Provincial level population distribution data pertaining towomen were obtained from the Statistical Centre of Iran. Agestandardizedincidence rates of BC and OC were gathered fromthe National Cancer Registry. Human Development Index wasused as the provinces’ social rank (SR), and rate ratio and Kunstand Mackenbach relative index of inequality were used to assesssocial disparities. Annual percentage change (APC) was calculatedusing joinpoint regression, and Spearman rank correlation wasused to examine the association between APC and SR. Results: Itwas found that over the study period, annual incidence rates roseby 11.6% and 9.7% for BC and OC, respectively. Social disparitieswere substantial and stable in favor of provinces with lowerSR in Iran, and were more profound for BC than OC. Correlationsbetween APC and SR were small and nonsignificant for both BCand OC. Conclusion: The results showed that both BC and OC incidenceincreased in Iran during 2003 to 2009. There were positiveassociations between BC and OC incidence rates and theprovinces’ SR. This study’s recommendations provide valuableinformation for health resource allocation pertaining to BC andOC control programs across provinces in Iran.

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