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Huang, Gang,Zhang, Chunfu,Li, Shunzi,Khemtong, Chalermchai,Yang, Su-Geun,Tian, Ruhai,Minna, John D.,Brown, Kathlynn C.,Gao, Jinming Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.35
<P>Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T<SUB>2</SUB> relaxivity. The nanoprobes are specific in targeting α<SUB>v</SUB>β<SUB>6</SUB>–expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.</P> <P>Graphic Abstract</P><P>Surface functionalization of SPIO nanoparticles with lung cancer peptides enables the specific targeting to α<SUB>v</SUB>β<SUB>6</SUB>–positive H2009 cancer cells, verified by cell uptake and MR imaging. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b902358e'> </P>