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RISS 인기검색어
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- 저자 : Kejiang Cao (검색결과 2 건)
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Inhibiting N-Cadherin-Mediated Adhesion Affects Gap Junction Communication in Isolated Rat Hearts
Zhu, Hongjun,Wang, Hegui,Zhang, Xiwen,Hou, Xiaofeng,Cao, Kejiang,Zou, Jiangang Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.3
Cadherin-mediated adherens junctions is impaired concomitant with a decrease in connexin 43 (Cx43) in diseases or pathological processes. We have investigated the acute effects of adherens junction impairment in isolated rat hearts by introducing Ala-His-Ala-Val-Asp-$NH_2$ (AHAVD, a synthetic peptide) as a specific inhibitor of N-cadherin. Effect of AHAVD on N-cadherin mediated adhension was analyzed by Cardiomy-ocyte aggregation assay. Laser confocal microscopy showed disrupted cell-cell contacts in cultured neonatal cardiomyocytes co-incubated with 0.2 mM AHAVD. In isolated adult rat hearts, Cx43 was redistributed along the bilateral of cardiomyocytes from the intercalated discs and significant dephosphorylation of Cx43 on serine368 occurred concomitantly with decreased gap junction (GJ) function in dose dependent manner after 1 h perfusion with AHAVD. These results indicate that impairing cad-herin-mediated adhesion by AHAVD rapidly results in Cx43 redistribution and dephosphorylation of serine368, thereby impairing GJ communication function.
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Inhibiting N-Cadherin-Mediated Adhesion Affects Gap Junction Communication in Isolated Rat Hearts
Hongjun Zhu,Hegui Wang,Xiwen Zhang,Xiaofeng Hou,Kejiang Cao,Jiangang Zou 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.3
Cadherin-mediated adherens junctions is impaired conco-mitant with a decrease in connexin 43 (Cx43) in diseases or pathological processes. We have investigated the acute effects of adherens junction impairment in isolated rat hearts by introducing Ala-His-Ala-Val-Asp-NH2 (AHAVD, a synthetic peptide) as a specific inhibitor of N-cadherin. Effect of AHAVD on N-cadherin mediated adhension was analyzed by Cardiomy-ocyte aggregation assay. Laser confocal microscopy showed disrupted cell-cell contacts in cultured neonatal cardiomyocytes co-incubated with 0.2 mM AHAVD. In isolated adult rat hearts, Cx43 was redis-tributed along the bilateral of cardiomyocytes from the intercalated discs and significant dephosphorylation of Cx43 on serine368 occurred concomitantly with decreased gap junction (GJ) function in dose dependent manner after 1 h perfusion with AHAVD. These results indicate that im-pairing cad-herin-mediated adhesion by AHAVD rapidly results in Cx43 redistribution and dephosphorylation of serine368, thereby impairing GJ communication function.
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