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Tomoyoshi Shibuya,Keiichi Haga,Masato Kamei,Koki Okahara,Shoko Ito,Masahito Takahashi,Osamu Nomura,Takashi Murakami,Masae Makino,Tomohiro Kodani,Dai Ishikawa,Naoto Sakamoto,Taro Osada,Tatsuo Ogihara,S 대한장연구학회 2018 Intestinal Research Vol.16 No.3
Ulcerative colitis (UC) is 1 of the 2 major phenotypes of chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms that impair function and quality of life. Further, IBD often affects women during childbearing age. Indeed, UC activity frequently increases during pregnancy, and the medications used to induce remission may adversely affect the health of the mother and the unborn child. We report successful induction of a remission in a UC case who experienced a flare-up in the first trimester of pregnancy. Upon relapse, she was treated with steroids and adsorptive granulomonocytapheresis (GMA) with the Adacolumn plus tacrolimus. This combination therapy induced a stable remission that was maintained during her entire pregnancy. She gave birth to a healthy child at 36 weeks of pregnancy with no maternal or fetal complications. Our experience indicates that GMA, as a non-drug therapeutic intervention with a favorable safety profile, plus tacrolimus might be a relevant treatment option for patients with active IBD during pregnancy. A future study of a large cohort of pregnant patients should strengthen our findings.
A System Concept for EFD/CFD Integration
Shigeya Watanabe,Shigeru Kuchi-ishi,Hiroyuki Kato,Takeshi Aoyama,Keiichi Murakami,Atsushi Hashimoto,Naoyuki Fujita,Yuichi Matsuo 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
A trail towards integration of EFD (Experimental Fluid Dynamics) and CFD (Computational Fluid Dynamics), that is. the development of a system called Digital/Analog Hybrid Wind Tunnel, is introduced. The aim of the system is to improve efficiency, accuracy, and reliability of aerodynamic characteristics evaluation in aerospace vehicle developments through mutual support between EFD and CFD. The function of the system consists of optimization of test planning utilizing pretest CFD calculations, an accurate correction of the wind tunnel wall and support interaction effects through CFD, CFD data refinement based on EFD data, the most probable aerodynamic characteristics estimation based on both EFD and CFD data, database including EFD and CFD data at an identical condition, and so forth. Key technical challenges in the system development, such as an automatic grid generation and high-speed solver development for CFD, a highly efficient data reduction technique for image measurement data. and techniques integrating EFD and CFD. are addressed.