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        Interfraction variation and dosimetric changes during image-guided radiation therapy in prostate cancer patients

        Fuchs, Frederik,Habl, Gregor,Devecka, Michal,Kampfer, Severin,Combs, Stephanie E.,Kessel, Kerstin A. The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.2

        Purpose: The aim of this study was to identify volume changes and dose variations of rectum and bladder during radiation therapy in prostate cancer (PC) patients. Materials and Methods: We analyzed 20 patients with PC treated with helical tomotherapy. Daily image guidance was performed. We re-contoured the entire bladder and rectum including its contents as well as the organ walls on megavoltage computed tomography once a week. Dose variations were analyzed by means of Dmedian, Dmean, Dmax, V<sub>10</sub> to V<sub>75</sub>, as well as the organs at risk (OAR) volume. Further, we investigated the correlation between volume changes and changes in Dmean of OAR. Results: During treatment, the rectal volume ranged from 62% to 223% of its initial volume, the bladder volume from 22% to 375%. The average Dmean ranged from 87% to 118% for the rectum and 58% to 160% for the bladder. The Pearson correlation coefficients between volume changes and corresponding changes in Dmean were -0.82 for the bladder and 0.52 for the rectum. The comparison of the dose wall histogram (DWH) and the dose volume histogram (DVH) showed that the DVH underestimates the percentage of the rectal and bladder volume exposed to the high dose region. Conclusion: Relevant variations in the volume of OAR and corresponding dose variations can be observed. For the bladder, an increase in the volume generally leads to lower doses; for the rectum, the correlation is weaker. Having demonstrated remarkable differences in the dose distribution of the DWH and the DVH, the use of DWHs should be considered.

      • KCI등재

        Interfraction variation and dosimetric changes during imageguided radiation therapy in prostate cancer patients

        Frederik Fuchs,Gregor Habl,Michal Deveč,ka,Severin Kampfer,Stephanie E,Combs,Kerstin A,Kessel 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.2

        Purpose: The aim of this study was to identify volume changes and dose variations of rectum and bladder during radiation therapy in prostate cancer (PC) patients. Materials and Methods: We analyzed 20 patients with PC treated with helical tomotherapy. Daily image guidance was performed. We re-contoured the entire bladder and rectum including its contents as well as the organ walls on megavoltage computed tomography once a week. Dose variations were analyzed by means of Dmedian, Dmean, Dmax, V 10 to V 75 , as well as the organs at risk (OAR) volume. Further, we investigated the correlation between volume changes and changes in Dmean of OAR. Results: During treatment, the rectal volume ranged from 62% to 223% of its initial volume, the bladder volume from 22% to 375%. The average Dmean ranged from 87% to 118% for the rectum and 58% to 160% for the bladder. The Pearson correlation coefficients between volume changes and corresponding changes in Dmean were -0.82 for the bladder and 0.52 for the rectum. The comparison of the dose wall histogram (DWH) and the dose volume histogram (DVH) showed that the DVH underestimates the percentage of the rectal and bladder volume exposed to the high dose region. Conclusion: Relevant variations in the volume of OAR and corresponding dose variations can be observed. For the bladder, an increase in the volume generally leads to lower doses; for the rectum, the correlation is weaker. Having demonstrated remarkable differences in the dose distribution of the DWH and the DVH, the use of DWHs should be considered.

      • Effects of Resonances in Corrugated Horn Antennas for a 22-GHz Balancing Radiometer

        DeWachter, E.,Murk, A.,Straub, C.,Haefele, A.,Soohyun Ka,Jung Jin Oh,Kampfer, N. IEEE 2009 IEEE geoscience and remote sensing letters Vol.6 No.1

        <P>The Stratospheric WAter vapor RAdiometer (SWARA) is a microwave radiometer designed for ground-based measurements of water vapor (H<SUB>2</SUB>O) in the middle atmosphere (20 to 80 km), including the stratosphere and mesosphere. The instrument is operating in a noncryogenic balancing calibration mode. Since its deployment, features have been observed in the spectrum which can be attributed to resonant variations of the antenna pattern of the corrugated horn. This paper presents copolar and crosspolar antenna pattern measurements of two sister antennas of the SWARA horn, as well as water vapor measurements from both antennas on the ground-based microwave radiometer <B>MI</B> ddle Atmospheric <B>W</B>Ater vapor <B>RA</B> diometer. We show that small irregularities in the frequency spectrum at the -20-dB level are visible in the copolar pattern, which, due to the balancing operation scheme used for the radiometer, lead to features in the spectrum that have the same or even higher brightness temperature as the line of interest.</P>

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