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- 저자 : Kamlesh Kumar Pant (검색결과 2 건)
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Sunil Kumar Gupta,Sarita Singh,Anuradha Nischal,Kamlesh Kumar Pant,Prahlad Kishore Seth 한국유전학회 2014 Genes & Genomics Vol.36 No.1
Mosquito-borne flaviviruses (MBFVs) areimportant cause of emerging and re-emerging human diseasesnearly worldwide, transmitted by arthropod vectors(mostly aedes and culex mosquitoes), with particular referenceto yellow fever virus, Japanese encephalitis virus,dengue fever virus, St. Louis encephalitis virus, MurrayValley encephalitis virus, etc. In over 100 countries, morethan 2.5 billion people are at risk of infection, andapproximately 20 million infections are reported annually. Through the analysis of gene sequence data of these viruspopulations it is possible to infer phylogenetic relationships,which in turn can yield important epidemiologicalinformation, including their demographic history. Earlyattempts to define the evolutionary relationships and originsof viruses in the genus flavivirus are hampered by thelack of genetic information particularly amongst theMBFVs. In this study, complete genome, translated polyprotein,structural and non-structural proteins of MBFVshave been targeted and revealed an extensive series ofclades defined by their epidemiology and disease associations. The branching patterns of at the deeper nodes of theresultant trees were different from those reported in theprevious study. The significance of these observations isdiscussed.
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Dwivedi, Shailendra,Singh, Sarvesh,Goel, Apul,Khattri, Sanjay,Mandhani, Anil,Sharma, Praveen,Misra, Sanjeev,Pant, Kamlesh Kumar Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic variants at -607 C/A-137G/C and -819C/T,-592C/A, respectively, may generate susceptibility and severity risk with various modes of tobacco exposure in prostate carcinoma (PCa) patients. IL-18 is a pro-inflammatory cytokine expressed on various cells including prostate gland elements, and is a key mediator of immune responses with anti-cancerous properties. IL-10 is an anti-inflammatory cytokine that is associated with tumour malignancy which causes immune escape. Materials and Methods: The present study was conducted with 540 subjects, comprising 269 prostate carcinoma patients and 271 controls. Genotyping was performed by PCR-RFLP and confirmed by real time PCR probe-based methods. Results: The findings indicated that the mutant heterozygous and homozygous genotype CC and GC+CC showed significant negative associations (p=0.01, OR=0.21; 95% CI: 0.08-0.51 and p=0.011, OR=0.43; 95% CI: 0.22-0.81, respectively) thus, less chance to be diagnosed as cancer against GG genotype of tobacco smoking patients. In addition, a heterozygous GC genotype at the same locus of IL-18 pro-inflammatory cytokine may aggravate the severity (OR=2.82; 95%CI 1.09-7.29 :p=001) so that patients are more likely to be diagnosed in advanced stage than with the GG wild homozygous genotype. Our results also illustrated that anti-inflammatory cytokine (IL-10) genetic variants, although showing no significant association with susceptibility to cancer of the prostate, may gave profound effects on severity of the disease, as -819 TC (OR=4.60; 95%CI 1.35-15.73), and -592 AC (OR=5.04; 95%CI 1.08-25.43) of IL-10 in tobacco chewers and combined users (both chewers and smokers) respectively, are associated with diagnosis in more advanced stage than with other variants. Conclusions: We conclude that promoter genetic variants of IL-18 and IL-10 with various modes of tobacco exposure may affect not only susceptibility risk but also severity in prostate cancer.
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