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Raiees Andrabi,Rajesh Kumar,Manju Bala,Ambili Nair,Prakash SS,Vandana Kushwaha,Kalpana Luthra 한국미생물학회 2012 The journal of microbiology Vol.50 No.5
Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
Alok Kumar Choudhary,Raiees Andrabi,Somi Sankaran Prakash,Rajesh Kumar,Shubhasree Dutta Choudhury,Naveet Wig,Ashutosh Biswas,Anjali Hazarika,Kalpana Luthra 한국미생물학회 2012 The journal of microbiology Vol.50 No.1
We assessed the anti-V3 antibody content and viral neutralization potential of the plasma of 63 HIV-1-infected patients (antiretroviral naïve=39, treated=24) against four primary isolates (PIs) of clade C and a tier 1 clade B isolate SF162. Depletion and inhibition of anti-V3 antibodies in the plasma of five patients with high titers of anti-V3 antibodies led to modest change in the neutralization percentage against two PIs (range 0–21%). The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naïve plasmas against the four PIs tested which was further evidenced by a follow-up study.