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RISS 인기검색어
- 검색키워드
- 저자 : K.V.P. Chandra Mohan (검색결과 3 건)
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S. Nagini,K.V.P. Chandra Mohan,V. Bhuvaneswari,S.K. Abraham 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.3
This study was designed to investigate the protective role of pretreatment with graded doses of freshly pre-pared tomato paste against 7,12-dimethylbenz[a]anthracene (DMBA)-induced genetic damage and oxidative stress in maleSwiss mice. The incidence of bone marrow micronuclei and the extent of hepatic lipid peroxidation and the antioxidants glu-tathione, glutathione peroxidase, and glutathione S-transferase were monitored. Three different concentrations (0.5, 1, and 2g/kg body weight) of tomato paste were tested for their anticlastogenic effects against DMBA (35 mg/kg body weight). In-creased frequency of micronuclei and enhanced lipid peroxidation accompanied by compromised antioxidant defenses wereobserved in DMBA-treated animals. Pretreatment with all three doses of tomato paste significantly reduced the frequenciesof DMBA-induced micronuclei and oxidative stress. These findings demonstrate that administration of tomato paste protectsagainst the clastogenic effects of DMBA by decreasing lipid peroxidation and enhancing the antioxidant status.
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S. Nagini,K.V.P. Chandra Mohan,R. Subapriya,Y. Hara 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
We evaluated the comparative chemopreventive efficacy of green tea polyphenols (polyphenon-E) and blacktea polyphenols (polyphenon-B) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcino-genesis. Lipid peroxidation, reduced and oxidized glutathione (GSH and GSSG, respectively), and the GSH-dependent en-zymes glutathione peroxidase and glutathione S-transferase in the erythrocytes were used as biomarkers of chemoprevention.Enhanced lipid peroxidation in erythrocytes of DMBA-treated animals was accompanied by a significant decrease in the an-tioxidant status. Dietary administration of polyphenon-E and -B to DMBA-treated animals significantly decreased the extentof lipid peroxidation and enhanced the levels of GSH, GSH/GSSG ratio, and activities of GSH-dependent enzymes. Our studyprovides evidence that polyphenon-B is more effective in inhibiting HBP carcinogenesis than polyphenon-E by enhancing theantioxidant status, suggesting that polyphenon-B may have a major impact in the chemoprevention of oral cancer.
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S. Nagini,S.K. Abraham,K.V.P. Chandra Mohan 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.1
We investigated the effects of pretreatment with tomato, garlic, and turmeric, alone and in combination, against7,12-dimethylbenz[a]anthracene (DMBA)-induced genetic damage and oxidative stress in male Swiss mice. Measurement ofthe incidence of bone marrow micronuclei as well as the extent of lipid peroxidation and the status of the antioxidants re-duced glutathione, glutathione peroxidase, and glutathione-S-transferase in the liver and erythrocytes were used as biomark-ers of chemoprotection. In DMBA-treated animals, increased frequency of bone marrow micronuclei was accompanied by en-hanced lipid peroxidation and antioxidant depletion. Pretreatment with tomato, garlic, and turmeric alone and a combinationof these agents significantly reduced the frequencies of DMBA-induced bone marrow micronuclei as well as the extent oflipid peroxidation. These changes may be mediated by the antioxidant-enhancing effects of the dietary agents. The results ofthe present study suggest that a diet containing even low levels of different naturally occurring compounds is effective in ex-erting antigenotoxic effects by inhibiting DMBA-induced oxidative stress.
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