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- 저자 : K. Kala (검색결과 3 건)
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K. Kala,M. Sundara Ganeasan,V. Balasubramani,J. Manovasuki,K. Valivittan,T.M. Sridhar,M.R. Kuppusamy 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.2
Recent efforts towards the treatment of bone defects and diseases focus on the development of bone scaffolds. Bioceramicsprovide strength, osteoconductivity and also imparts flexibility and resorbability. In this study, the biodegradable compositeswere fabricated using bioactive nano Hydroxyapatite (n-HAP) and bioresorbable nano β-Tricalcium phosphate (n-β-TCP)taken in 1:1 proportion. The nano composite scaffolds were synthesized using PEG (Poly Ethylene Glycol) by wet precipitationmethod. XRD (X-ray diffraction) confirms the presence of crystalline structure of n-HAP and n-β-TCP within the lattice. FESEM (Field Emission Scanning Electron Microscopy) and EDS (Energy Dispersion X-ray Spectroscopy) confirms the microporous nature and the phase purity of the composite. Further, biochemical studies were carried out using MG-63 Osteoblastcell line to evaluate their sustainability after implantation. The viability of the cells and proliferation rate is evaluated using3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) with different concentration and different incubationperiod. The ALP (Alkaline Phosphotase) test reveals that the composite favours bone regeneration through apatite layerformation. Further studies were carried out to explore the DPPH (1,1-diphenyl-2-picrylhydrazyl) activity on the compositesand results reveals that the composite have an ability to trap the free radicals in the biological surroundings. The antimicrobialstudies indicate that the composites shows no major inhibitory effects towards the most common bone affecting bacteriaStaphylococcus aureus. The studies indicate that the concentration range of the composite is ideal for bone growth and can beused as substituents in the scaffold synthesis for normal and cancerous patients.
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( Kala K. U. ),( M. Nandhini ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.2
Recommender Systems (RecSys) have a major role in e-commerce for recommending products, which they may like for every user and thus improve their business aspects. Although many types of RecSyss are there in the research field, the state of the art RecSys has focused on finding the user similarity based on sequence (e.g. purchase history, movie-watching history) analyzing and prediction techniques like Recurrent Neural Network in Deep learning. That is RecSys has considered as a sequence prediction problem. However, evaluation of similarities among the customers is challenging while considering temporal aspects, context and multi-component ratings of the item-records in the customer sequences. For addressing this issue, we are proposing a Deep Learning based model which learns customer similarity directly from the sequence to sequence similarity as well as item to item similarity by considering all features of the item, contexts, and rating components using Dynamic Temporal Warping(DTW) distance measure for dynamic temporal matching and 2D-GRU (Two Dimensional-Gated Recurrent Unit) architecture. This will overcome the limitation of non-linearity in the time dimension while measuring the similarity, and the find patterns more accurately and speedily from temporal and spatial contexts. Experiment on the real world movie data set LDOS-CoMoDa demonstrates the efficacy and promising utility of the proposed personalized RecSys architecture.
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Antiulcer Activity of Sida acuta Burm.
P. Malairajan,Geetha Gopalakrishnan,S. Narasimhan,K. Jessi Kala Veni 한국생약학회 2006 Natural Product Sciences Vol.12 No.3
ethanol extract of Sida acuta Burm. (ALSA) whole plant was studied for its anti-ulcer activityagainst aspirin plus pylorous ligation induced gastric ulcer, HCl-ethanol induced ulcer, and water immersion stressinduced ulcer (WISIU) in rats. We found that ALSA at a dose of 300 mg/kg, (orally) markedly decrease theindex (53.69%). It has not reduced the total acidity significantly and no significant change in pH. It also showed55.14% gastro protective activity, whereas standard drug sucralfate showed 94.85%. WISIU showed protectionindex 24.4%, whereas standard drug omeprazole (OMEZ) showed protection index 100%. Keywordsantiulcer, Sida acuta, aspirin plus pylorous ligation ulceration, HCl-ethanol ulceration, waterimmersion stress ulcer
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