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Micro/Nanotechnology for Cancer Immunotherapy
Junsang Doh(도준상) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Cancer immunotherapy has recently been successful in the treatment of various types of tumors. Cytotoxic lymphocytes, including cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, play an essential role in elimination of tumors by directly killing tumor cells. Therefore, evaluation of lymphocyte cytotoxicity against tumor cells is critical for the improvement of cancer immunotherapy. Lymphocyte cytotoxicity is a strictly regulated function requiring a multi-step “checkpoint” to minimize normal cell damage. However, current cytotoxicity assays mostly provide information about final outcomes of cytotoxicity. To overcome this limitation, we are developing new assays that allow “stepwise” evaluation of lymphocyte cytotoxicity using dynamic imaging and microfabrication techniques.
Doh, Junsang,Krummel, Matthew F Springer-Verlag 2010 Current topics in microbiology and immunology Vol.340 No.-
<P>The cell-biology of intercellular communication between T cells and their partners has been greatly advanced over the past 10 years. The key morphological and motility features of cell contact-based communication between T cells and APCs can now be seen as a collection of patterns for cell-cell interactions amongst immune cells more generally, each serving to contribute to the outcome of the contact both locally and globally. Here we review the conservation of these patterns, amongst which is the emergent 'immunological synapse,' and describe a newly defined example, formed between the adjacent activating T cells. We subsequently seek to put these and the pattern more generally into the framework of system-wide behavior of the immune system. We postulate that the patterns are fine-tuned to provide quorum-like decisions by collections of activating and activated cells that interact over time and space.</P>
도준상(Junsang Doh) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
Immune system is composed of multiple cells with distinct functions, and immune responses are orchestrated by complex and dynamic cell-cell interactions. Therefore, each cell behavior and function should be understood under right spatio-temporal context. Studying such complexity and dynamics has been challenging with conventional biological tools. Recent development of new technologies such as state of art imaging instruments and microfabrication techniques compatible with biological systems have provided many exciting opportunities to dissect complex and dynamic immune cell interactions; new microscopy techniques enable us to observe stunning dynamics of immune system in real time. Microfabrication permits us to manipulate microenvironments governing molecular/cellular dynamics of immune cells to study detailed mechanisms of phenomena observed by microscopy. Also, microfabrication can be used to engineer microenvironments optimal for specific imaging techniques. In this presentation, I am going to present an example of how these two techniques can be combined to tackle challenging problems in immunology. Obviously, this strategy can readily be applied to many different fields of biology other than immunology.
Choi, Jong-Cheol,Doh, Junsang Royal Society of Chemistry 2012 Lab on a chip Vol.12 No.23
<P>A new method for the high-throughput study of cell spreading dynamics is devised by multi-step microscopy projection photolithography based on a cell-friendly photoresist. By releasing a large number of rounded cells in single cell arrays and monitoring their spreading dynamics by interference reflection microscopy, a large number of cell spreading data can be acquired by a single experiment.</P>