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- 저자 : Junchen Wang (검색결과 3 건)
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Spindle Spinel CoFeCoO4 Microparticles/rGO as an Oxygen Reduction and Oxygen Evolution Catalyst
Bowen Wang,Nian Tao,Junchen Liu,Hao Wang,Yinxiao Du,Hujiang Yang,Yonggang Wang,Kai Huang,Ru Zhang,Ming Lei 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.4
The representative spinel-type materials AB2O4 (both A and B are transition metals) electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) have been investigated and significant improvements have been achieved in the activity and durability for ORR and OER in the alkaline solution. But CoFeCoO4 was not explored widely like ZnCo2O4 (or NiCo2O4) as the ORR electrocatalyst for its relatively complicated atomic site occupation. CoFeCoO4 has a typical cubic spinel structure with Co2+ in the tetrahedron and Co3+ and Fe3+ in the octahedron. A mixture of Co3+ and Fe3+ in the B site makes the oxide have a wider overlap between transition metal 3d orbit and O 2p orbit, which can lead to an effective charge transfer in the rate-determining steps of ORR process and then enhance the ORR activity. The high electronic conductivity and specific surface area of rGO can accelerate charger transfer and provide more catalytic sites, which would contribute to a faster ORR process. In this work, the porous spindle CoFeCoO4 microparticles which were synthesized by hydrothermal technology, were assembled on the rGO surface to obtain the CoFeCoO4/rGO composite, which exhibited enhanced ORR activity and catalytic stability comparable to that of Pt/C. On the other hand, the OER catalytic activity of the prepared samples was also studied to explore the potential of CoFeCoO4/rGO as a bifunctional oxygen catalyst.
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Shanjie Wang,Kegong Chen,Ye Wang,Zeng Wang,Zhaoying Li,JunChen Guo,Jianfeng Chen,Wenhua Liu,Xiaohui Guo,Guangcan Yan,Chenchen Liang,Huai Yu,Shaohong Fang,Bo Yu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has been considered a promising drug and gene delivery system to the target tissue. We aim to investigate whether cardiac gene delivery of melatonin receptor mediated by UTMD technology optimizes the efficacy of clinically equivalent dose of melatonin in sepsis-induced cardiomyopathy. Methods Melatonin and cardiac melatonin receptors in patients and rat models with lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-induced sepsis were assessed. Rats received UTMD-mediated cardiac delivery of RORα/cationic microbubbles (CMBs) at 1, 3 and 5 days before CLP surgery. Echocardiography, histopathology and oxylipin metabolomics were assessed at 16–20 h after inducing fatal sepsis. Results We observed that patients with sepsis have lower serum melatonin than healthy controls, which was observed in the blood and hearts of Sprague–Dawley rat models with LPS- or CLP-induced sepsis. Notably, a mild dose (2.5 mg/kg) of intravenous melatonin did not substantially improve septic cardiomyopathy. We found decreased nuclear receptors RORα, not melatonin receptors MT1/2, under lethal sepsis that may weaken the potential benefits of a mild dose of melatonin treatment. In vivo, repeated UTMD-mediated cardiac delivery of RORα/CMBs exhibited favorable biosafety, efficiency and specificity, significantly strengthening the effects of a safe dose of melatonin on heart dysfunction and myocardial injury in septic rats. The cardiac delivery of RORα by UTMD technology and melatonin treatment improved mitochondrial dysfunction and oxylipin profiles, although there was no significant influence on systemic inflammation. Conclusions These findings provide new insights to explain the suboptimal effect of melatonin use in clinic and potential solutions to overcome the challenges. UTMD technology may be a promisingly interdisciplinary pattern against sepsis-induced cardiomyopathy.
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Xiaohui Zhang,Xuquan Ji,Junchen Wang,Yubo Fan,Chunjing Tao 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.2
real-time for laparoscopic image-guided navigation. The stereo vision method for intraoperative tissue 3D reconstructionhas the most potential for clinical development benefiting from its high reconstruction accuracy and laparoscopy compatibility. However, existing stereo vision methods have difficulty in achieving high reconstruction accuracy in real time. Also,intraoperative tissue reconstruction results often contain complex background and instrument information that preventsclinical development for image-guided systems. Taking laparoscopic partial nephrectomy (LPN) as the research object, thispaper realizes a real-time dense reconstruction and extraction of the kidney tissue surface. The central symmetrical Censusbased semi-global block stereo matching algorithm is proposed to generate a dense disparity map. A GPU-based pixel-bypixelconnectivity segmentation mechanism is designed to segment the renal tissue area. An in-vitro porcine heart, in-vivoporcine kidney and offline clinical LPN data were performed to evaluate the accuracy and effectiveness of our approach. The algorithm achieved a reconstruction accuracy of ± 2 mm with a real-time update rate of 21 fps for an HD image size of960 × 540, and 91.0% target tissue segmentation accuracy even with surgical instrument occlusions. Experimental resultshave demonstrated that the proposed method could accurately reconstruct and extract renal surface in real-time in LPN. Themeasurement results can be used directly for image-guided systems. Our method provides a new way to measure geometricinformation of target tissue intraoperatively in laparoscopy surgery.
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