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- 저자 : Julie O. Denenberg (검색결과 1 건)
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Association Between Perirenal Fat Thickness and Renal and Systemic Calcified Atherosclerosis
구보경,Julie O. Denenberg,C. Michael Wright,Michael H. Criqui,Matthew A. Allison 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.1
Background: We investigated associations between perirenal fat thickness and atherosclerotic calcification in six different vascularbeds. Methods: Using a community-based cohort (n=3,919), perirenal fat thickness was estimated from computed tomography scans. Itwas classified as Q1 (the lowest quartile) to Q4 (the highest quartile) in each sex. Calcification in the carotid arteries, coronary arteries, thoracic aorta, abdominal aorta, iliac arteries, and renal arteries was evaluated. Results: Perirenal fat thickness was associated with older age (P<0.01) and a higher prevalence of obesity, hypertension, and dyslipidemia (P<0.01 for all). Perirenal fat thickness was independently associated with renal arterial calcification even after adjustment for age, sex, body mass index, hypertension, dyslipidemia, smoking history, and family history of heart diseases in first-degreerelatives (odds ratio [OR] per quartile of perirenal fat thickness, 1.25; 95% confidence interval [CI], 1.09 to 1.44). Compared to Q1,the odds of renal arterial calcification in Q4 was about two times higher (OR, 2.05; 95% CI, 1.29 to 3.25). After adjustment for renalarterial calcification and atherosclerotic risk factors, the only other vascular bed where perirenal fat thickness showed a significantassociation with calcification was the abdominal aorta (OR, 1.11; 95% CI, 1.00 to 1.23; P=0.045). Conclusion: Perirenal fat thickness was independently associated with vascular calcification in the renal artery and abdominal aorta.
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