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RISS 인기검색어
- 검색키워드
- 저자 : Jonathan R. Lindner (검색결과 2 건)
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A Primer on the Methods and Applications for Contrast Echocardiography in Clinical Imaging
설상훈,Jonathan R. Lindner 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.3
Contrast echocardiography is broadly described as a variety of techniques whereby the blood pool on cardiac ultrasound isenhanced with encapsulated gas-filled microbubbles or other acoustically active nano- or microparticles. The development of thistechnology has occurred primarily in response to the need improve current diagnostic applications of echocardiography such asthe need to better define left ventricular cavity volumes, regional wall motion, or the presence or absence of masses and thrombi. A secondary reason for the development of contrast echocardiography has been to expand the capabilities of echocardiography. These new applications include myocardial perfusion imaging for detection of ischemia and viability, perfusion imaging ofmasses/tumors, and molecular imaging. The ability to fill all of these current and future clinical roles has been predicated on theability to produce robust contrast signal which, in turn, has relied on technical innovation with regards to the microbubblecontrast agents and the ultrasound imaging paradigms. In this review, we will discuss the basics of contrast echocardiographyincluding the composition of microbubble contrast agents, the unique imaging methods used to optimize contrast signal-tonoiseratio, and the clinical applications of contrast echocardiography that have made a clinical impact.
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Cardiovascular Molecular Imaging with Contrast Ultrasound: Principles and Applications
심지영,Jonathan R. Lindner 대한심장학회 2014 Korean Circulation Journal Vol.44 No.1
Methods for imaging the molecular or cellular profile of tissue are being developed for all forms of non-invasive cardiovascular imaging. It is thought that these technologies will potentially improve patient outcomes by allowing diagnosis of disease at an early-stage, moni-toring disease progression, providing important information on patient risk, and for tailoring therapy to the molecular basis of disease. Molecular imaging is also already assuming an important role in science by providing a better understanding of the molecular basis ofcardiovascular pathology, for assessing response to new therapies, and for rapidly optimizing new or established therapies. Ultrasound-based molecular imaging is one of these new approaches. Contrast-enhanced ultrasound molecular imaging relies on the detection ofnovel site-targeted microbubbles (MB) or other acoustically active particles which are administered by intravenous injection, circulatethroughout the vascular compartment, and are then retained and imaged within regions of disease by ligand-directed binding. The tech-nique is thought to be advantageous in practical terms of cost, time, and ease of use. The aim of this review is to discuss the molecularparticipants of cardiovascular disease that have been targeted for ultrasound imaging, general features of site-targeted MB, imaging pro-tocols, and potential roles of ultrasound molecular imaging in cardiovascular research and clinical medicine.
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