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RISS 인기검색어
- 검색키워드
- 저자 : John A. Polagruto (검색결과 2 건)
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Robert M. Hackman,John A. Polagruto,Heidrun B. Gross,Faranak Kamangar,Ken-Ichi Kosuna,Buxiang Sun,Hajime Fujii,Carl L. Keen 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4
Epidemiological studies suggest that a high dietary intake of flavanols, a subclass of flavonoids, is associatedwith reduced risk of vascular disease. Clinical studies have also shown that the consumption of certain flavanol-rich foods(e.g., cocoa, tea, red wine), as well as intake of the individual flavanol (-)-epicatechin, can result in improvement in a num-ber of parameters associated with vascular disease, including improved endothelial function, reduced platelet reactivity, andreduced oxidative stress. The present study assessed the effects of a flavanol-rich supplement on platelet reactivity and plasmaoxidant defense in a group of smokers, a population at an elevated risk for vascular disease. Male smokers were randomlyassigned to a placebo (n . 10) or a flavanol-rich grapeseed extract (FRGSE; n . 13) group, and after an overnight fast, bloodsamples were collected before and at 1, 2, and 6 hours following consumption of the placebo or supplement. The FRGSE sup-plement, but not the placebo, significantly decreased ADP-stimulated platelet reactivity at 1, 2, and 6 hours following intake(P. .05) compared to baseline levels. Similarly, the supplement, but not the placebo, decreased epinephrine-stimulated plateletreactivity 2 hours following consumption. Plasma antioxidant capacity (total radical trapping antioxidant potential), lipid ox-idation (plasma thiobarbituric acid-reactive substances), and serum uric acid concentrations were not affected in either group.Thus smokers may obtain some health benefits from the consumption of certain flavanol-rich foods, beverages, and supple-ments.
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Carl L. Keen,John A. Polagruto,Derek D. Schramm,Janice F. Wang-Polagruto,Luke Lee 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4
Diets rich in flavonoids have been associated with reduced risk for cardiovascular disease. This may be due,in part, to flavonoid-induced alterations in eicosanoid synthesis. Our objective was to identify plant-derived beverages that al-ter synthesis of prostacyclin in cultured human aortic endothelial cells (HAEC), and to determine if these beverages could al-ter in vivo6-keto-prostaglandin F 1a (a stable metabolite of prostacyclin) synthesis and platelet function. HAEC were treatedwith nine commonly consumed beverages to determine their effects on prostacyclin synthesis under acute and chronic treat-ment regimens. Orange, purple grape, and pomegranate juices and coffee (6 9 mL/kg) were then provided to 28 fasted, healthyadult subjects (eight men and 20 women) on five separate days. Plasma samples were collected immediately following juiceconsumption (baseline), and at 2 and 6 hours post-consumption. On an acute basis, administration of HAEC with pomegran-ate juice increased media prostacyclin. Chronic exposure to purple grape and pomegranate juice increased aortic endothelialcell prostacyclin synthesis (38% and 61%, respectively; P, .05). The consumption of purple grape, pomegranate, and orangejuice prolonged epinephrine/collagen-induced clotting time (P, .05). Purple grape juice increased plasma 6-keto-prostaglandinF1a (20%; P, .05) at 2 hours; pomegranate and orange juice did not significantly influence plasma prostacyclin concentra-tions. Consistent with the in vitrodata, coffee consumption did not influence clotting time or plasma prostacyclin concentra-tions. These results indicate that the HAEC model system can provide a qualitative means to screen food and food-derivedproducts for biologic activity related to cardiovascular health.
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