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RISS 인기검색어
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- 저자 : Jiu-Feng Wei (검색결과 2 건)
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Song, Wei-Feng,Wang, Lei,Huang, Wei-Yi,Cai, Xun,Cui, Jiu-Jie,Wang, Li-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background and Aims: MicroRNA-21 (miR-21) is reported to be overexpressed and to contribute to proliferation, apoptosis and gemcitabine resistance in pancreatic ductal adenocarcinomas (PDACs). The aims of this study were to explore regulation of miR-21 expression by epigenetic change and its impact on chemoresistance and malignant properties of of pancreatic cancer. Materials and methods: We retrospectively collected 41 cases of advanced pancreatic cancer patients who were sensitive or resistant to gemcitabine and assessed levels of serum circulating miR-21 for correlation with cytotoxic activity. Histone acetylation in the miR-21 promoter was also studied in gemcitabine-sensitive and gemcitabine-resistant PDAC cells. Gemcitabine-resistant HPAC and PANC-1 cells were transfected with pre-miR-21 precursors (pre-miR-21) and antisense oligonucleotides (anti-miR-21), and were treated with TSA. Finally, invasion and metastasis assays were performed and alteration in mir-21, PTEN, AKT and pAKT level was evaluated in these cells. Results: Serum miR-21 levels were increased in gemcitabine-resistant PDAC patients compared with gemcitabine-sensitive subjects. The miR-21 levels were increased in 6 PDAC cells treated with gemcitabine significantly, associated with 50% inhibitory concentrations ($IC_{50}s$). Histone acetylation levels at miR-21 promoter were increased in PDAC cells after treatment with gemcitabine. Enhanced invasion and metastasis, increased miR-21 expression, decreased PTEN, elevated pAKT level were demonstrated in gemcitabine-resistant HPAC and PANC-1 cells. Pre-miR-21 transfection or TSA treatment further increased invasion and metastasis ability, decreased PTEN, and elevated pAKT levels in these two lines. In contrast, anti-miR-21 transfection could reverse invasion and metastasis, and PTEN and pAKT expressions induced by gemcitabine. Conclusions: MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells.
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Areas of endemism for scale insects in China
Fang Wang,Chao-Zhong Jiang,Jingze Liu,Jiu-Feng Wei 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4
The identification of areas of endemism (AOEs) has been a major challenge in biogeography. In the present study, parsimony analysis of endemicity (PAE) was used to define the AOEs of scale insect species in China. A total of 11 Chinese scale insect endemic areas, Tianshan mountain (A2-B1), South Tibet (H2-H3), Eastern Qinling Mountain (E12-E13), Dalou mountain (G11-H11), West Yunnan (I9, J9-J10, K9), Hainan Island-South west Guangdong (M13-L14), South Guangdong (K15-K16), South Fujian (J17-J18), Center Zhejiang (H18-H19), Taiwan Island (K19-L19) and association of Henan and Hubei (F15-G16), had been identified based on a distribution database of 506 endemic scale insect species. The Chinese areas of scale insects endemism showed a remarkable mountain effect. Hainan and Taiwan islands showed considerable endemism. Moreover, most of these AOEs were found to be endemic sites for several other plants and animals. These results will provide important information for further studies on scale insects diversity in China.
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