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RISS 인기검색어
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- 저자 : Jipeng Guo (검색결과 2 건)
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Ferroptosis: A Novel Anti-tumor Action for Cisplatin
Jipeng Guo,Bingfei Xu,Qi Han,Hongxia Zhou,Yun Xia,Chongwen Gong,Xiaofang Dai,Zhenyu Li,Gang Wu 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the therapeutic role of ferroptosis in classic chemotherapy drugs, including the underlying mechanism. Materials and Methods Cell viability was detected by using the methylthiazoltetrazlium dye uptake method. RNAi was used to knockout iron-responsive element binding protein 2, and polymerase chain reaction, western blot was used to evaluate the efficiency. Intracellular reduced glutathione level and glutathione peroxidases activity were determined by related assay kit. Intracellular reactive oxygen species levels were determined by flow cytometry. Electron microscopy was used to observe ultrastructure changes in cell. Results Among five chemotherapeutic drugs screened in this study, cisplatin was found to be an inducer for both ferroptosis and apoptosis in A549 and HCT116 cells. The depletion of reduced glutathione caused by cisplatin and the inactivation of glutathione peroxidase played the vital role in the underlying mechanism. Besides, combination therapy of cisplatin and erastin showed significant synergistic effect on their anti-tumor activity. Conclusion Ferroptosis had great potential to become a new approach in anti-tumor therapies and make up for some classic drugs, which open up a new way for their utility in clinic.
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Sterically hindered amine-functionalized MCM-41 composite for efficient carbon dioxide capture
Fei Gao,Cailin Ji,Shougui Wang,Weiwen Wang,Jipeng Dong,Changqing Guo,Yuwen Gao,Guanghui Chen 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.8
A new adsorbent based on sterically hindered amine for efficient CO2 capture was prepared. Mesoporoussilicon MCM-41 was modified by sterically hindered amine AMPD (2-amino-2-methyl-1,3-propanediol) in differentAMPD loadings by a facile solid-state self-assembly approach. The physicochemical properties of the MCM-41@AMPDcomposites were analyzed using XRD, BET, FT-IR and SEM, and the composites were investigated for the CO2 captureperformance, including CO2 capture capacity, adsorption selectivity and cycling stability. Characterization analysesshowed that the AMPD active components were successfully incorporated and well dispersed into the mesoporous siliconMCM-41 surfaces. Adsorption results suggest that the modification by the active ingredient AMPD can significantlyimprove the CO2 capture performance. The MCM-41@AMPD material with an AMPD loading of 7mmol∙g1MCM-41 support exhibits a good CO2 adsorption capacity and CO2 adsorption selectivity, and shows excellent cyclingstability. Furthermore, the isosteric heat of CO2 adsorption on the MCM-41@AMPD-7 material was evaluated by theClausius-Clapeyron equation, and the value was 34-78 kJ∙mol1.
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