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- 저자 : Jingge Liu (검색결과 2 건)
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Jingge Liu,Ang Cao,Jing Si,Lihong Zhang,Qinglan Hao,Yuan Liu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.10
Sintering of the active metallic nanoparticles and carbon deposition are the key problems faced for CO methanation catalysts. For overcoming those problems, bimetallic nanocatalyst is a promising route. In this work, a series of Al2O3 supported Ni-Co alloy catalysts were prepared by reducing NiCoAl layered double hydrotalcite (LDHs), and characterized with X-ray diffraction (XRD), temperature programmed reduction TPR, N2 adsorption-desorption, transmission electron microscopy (TEM) and temperature programed oxidation (TPO) techniques. The resultant catalysts were mesoporous with nanoparticles of Ni-Co alloy ranging from 7.9 nm to 9.2 nm which were highly dispersed in alumina matrix. The sample Ni7Co3-Al2O3 catalysts showed very good catalytic performance during the stability test at 500/600℃ for 300 h, meanwhile exhibited excellent anti-sintering ability and anti-carbon deposition ability, owing to the formation of Ni-Co alloy and the feature of LDHs. This strategy for improving anti-sintering and anti-carbon deposition should be extendable for catalysts of other reactions.
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Hepatic microRNAome reveals potential microRNA-mRNA pairs association with lipid metabolism in pigs
Jingge Liu,Caibo Ning,Bo-jiang Li,Rongyang Li,Wang Jun Wu,Honglin Liu 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.9
Objective: As one of the most important metabolic organs, the liver plays vital roles in modulating the lipid metabolism. This study was to compare miRNA expression profiles of the Large White liver between two different developmental periods and to identify candidate miRNAs for lipid metabolism. Methods: Eight liver samples were collected from White Large of 70-day fetus (P70) and of 70-day piglets (D70) (with 4 biological repeats at each development period) to construct sRNA libraries. Then the eight prepared sRNA libraries were sequenced using Illumina next-generation sequencing technology on HiSeq 2500 platform. Results: As a result, we obtained 346 known and 187 novel miRNAs. Compared with the D70, 55 down- and 61 up-regulated miRNAs were shown to be significantly differentially expressed (DE). Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis indicated that these DE miRNAs were mainly involved in growth, development and diverse metabolic processes. They were predicted to regulate lipid metabolism through adipocytokine signaling pathway, mitogen-activated protein kinase, AMP-activated protein kinase, cyclic adenosine monophosphate, phosphatidylinositol 3 kinase/protein kinase B, and Notch signaling pathway. The four most abundantly expressed miRNAs were miR-122, miR-26a and miR-30a-5p (miR-122 only in P70), which play important roles in lipid metabolism. Integration analysis (details of mRNAs sequencing data were shown in another unpublished paper) revealed that many target genes of the DE miRNAs (miR-181b, miR-145-5p, miR-199a-5p, and miR-98) might be critical regulators in lipid metabolic process, including acyl-CoA synthetase long chain family member 4, ATP-binding casette A4, and stearyl-CoA desaturase. Thus, these miRNAs were the promising candidates for lipid metabolism. Conclusion: Our study provides the main differences in the Large White at miRNA level between two different developmental stages. It supplies a valuable database for the further function and mechanism elucidation of miRNAs in porcine liver development and lipid metabolism.
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