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Peng Zhang,Jingda Yu,Yifang Gui,Cui Sun,Weiping Han 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.11
Purpose: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) wasimplicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the role of miR-222-3p in SEB-inducedliver injury. Materials and Methods: Expression of miR-222-3p and suppressors of cytokine signaling 1 (SOCS1) was detected using real-timequantitative PCR and western blot. Liver injury was determined by levels of aspartate aminotransferase (AST), alanine aminotransferase(ALT), and inflammatory cytokines, numbers of infiltrating mononuclear cells using AST/ALT assay kit, enzyme-linked immunosorbentassay (ELISA), and hematoxylin-eosin staining, respectively. Target binding between miR-222-3p and SOCS1 waspredicted on targetScan software, and confirmed by luciferase reporter assay. Results: SEB induced liver injury in D-galactosamine (D-gal)-sensitized mice, as demonstrated by increased serum levels of ASTand ALT, elevated release of interferon-gamma (INF-γ), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-2, andpromoted infiltrating immune cells into liver. Expression of miR-222-3p was dramatically upregulated, and SOCS1 was downregulatedin SEB-induced liver injury both in mice and splenocytes. Moreover, miR-222-3p knockout (KO) mice exhibited alleviatedliver injury accompanied with SOCS1 upregulation. Besides, splenocytes under SEB challenge released less INF-γ, TNF-α, IL-6,and IL-2 during miR-222-3p knockdown. Mechanically, SOCS1 was targeted and downregulated by miR-222-3p. Upregulation ofSOCS1 attenuated INF-γ, TNF-α, IL-6, and IL-2 release in SEB-induced splenocytes; downregulation of SOCS1 could block thesuppressive role of miR-222-3p knockdown in SEB-induced splenocytes. Conclusion: Inhibition of miR-222-3p relieves SEB-induced liver inflammatory injury by upregulating SOCS1, thereby providingthe first evidence of miR-222-3p in SEB-induced liver injury.
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Liu Huan,Miao Yu,Tian Huayu,Chen Yishan,Wang Enfu,Huang Jingda,Zhang Wenbiao 한국탄소학회 2024 Carbon Letters Vol.34 No.3
Moso bamboo, as a kind of renewable functional material, exhibits outstanding development potential. It is promising to prepare activated carbon with good mechanical strength and high specific surface area using moso bamboo as raw material. In this work, we employed a hydraulic extruder to extrude the bamboo charcoal and the adhesive to obtain the moso bamboo activated carbon, and improved the specific surface area of the columnar activated carbon through high-temperature water vapor activation. Through the catalytic role of the water vapor activation process, the formation and expansion of the pores were promoted and the internal pores were greatly increased. The obtained columnar activated carbon shows excellent mechanical strength (93%) and high specific surface area (791.54 m2/g). Polyacrylamide@asphalt is one of the most effective adhesives in the high-temperature water vapor activation. The average pore size (22.99 nm) and pore volume (0.36 cm3/g) of the prepared columnar activated carbon showed a high mesoporous ratio (83%). Based on the excellent pore structure brought by the activation process, the adsorption capacity of iodine (1135.75 mg/g), methylene blue (230 mg/g) and carbon tetrachloride (64.03 mg/g) were greatly improved. The resultant moso bamboo columnar activated carbon with high specific surface area, excellent mechanical properties, and outstanding adsorption capacity possesses a wide range of industrial applications and environmental protection potential.
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