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Shao-rui Chen,Wen-ping Zhang,Jing-mei Bao,Zhong-bin Cheng,Sheng Yin 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Aristoyunnolin H is a novel aristophyllenesesquiterpenoid isolated from the traditional Chinese medicineAristolochia yunnanensis Franch. The presentresearch was designed to explore the anti-fibrotic effects ofaristoyunnolin H in adult rat cardiac fibroblasts (CFs)stimulated with angiotensin II (Ang II). Western blotanalysis data showed that aristoyunnolin H reduced theupregulation of fibronectin (FN), connective tissue growthfactor and collagen I(Col I) production induced by Ang II inCFs. By studying the dynamic intracellular changes ofCa2?, we further found that while aristoyunnolin H relievedthe calcium influx, it has no effect on intracellular calciumstore release. Meanwhile, aristoyunnolin H also inhibitedthe Ang II-stimulated phosphorylation of Ca2?/calmodulindependentprotein kinase II. In conclusion, aristoyunnolin Hmay attenuate extracellular matrix secretion in vitro byinhibiting Ang II-induced calcium signaling.