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      • KCI등재

        Generative Adversarial Networks: A Literature Review

        ( Jieren Cheng ),( Yue Yang ),( Xiangyan Tang ),( Naixue Xiong ),( Yuan Zhang ),( Feifei Lei ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.12

        The Generative Adversarial Networks, as one of the most creative deep learning models in recent years, has achieved great success in computer vision and natural language processing. It uses the game theory to generate the best sample in generator and discriminator. Recently, many deep learning models have been applied to the security field. Along with the idea of “generative” and “adversarial”, researchers are trying to apply Generative Adversarial Networks to the security field. This paper presents the development of Generative Adversarial Networks. We review traditional generation models and typical Generative Adversarial Networks models, analyze the application of their models in natural language processing and computer vision. To emphasize that Generative Adversarial Networks models are feasible to be used in security, we separately review the contributions that their defenses in information security, cyber security and artificial intelligence security. Finally, drawing on the reviewed literature, we provide a broader outlook of this research direction.

      • SCIESCOPUSKCI등재

        Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat

        Li, Xianwei,Shen, Yuanyuan,Lu, Yining,Yang, Jieren The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

        Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma is mediated by AR. Epalrestat is an aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Whether AR is involved in pathogenesis of pulmonary fibrosis and whether epalrestat attenuates pulmonary fibrosis remains unknown. Pulmonary fibrosis was induced by intratracheal instillation of bleomycin (5 mg/kg) in rats. Primary pulmonary fibroblasts were cultured to investigate the proliferation by BrdU incorporation method and flow cytometry. The expression of AR, TGF-${\beta}_1$, ${\alpha}$-SMA and collagen I was analyzed by immunohistochemisty, real-time PCR or western blot. In vivo, epalrestat treatment significantly ameliorated the bleomycin-mediated histological fibrosis alterations and blocked collagen deposition concomitantly with reversing bleomycin-induced expression up-regulation of TGF-${\beta}_1$, AR, ${\alpha}$-SMA and collagen I (both mRNA and protein). In vitro, epalrestat remarkably attenuated proliferation of pulmonary fibroblasts and expression of ${\alpha}$-SMA and collagen I induced by TGF-${\beta}_1$, and this inhibitory effect of epalrestat was accompanied by inhibiting AR expression. Knockdown of AR gene expression reversed TGF-${\beta}_1$-induced proliferation of fibroblasts, up-regulation of ${\alpha}$-SMA and collagen I expression. These findings suggest that AR plays an important role in bleomycin-induced pulmonary fibrosis, and epalrestat inhibited the progression of bleomycin-induced pulmonary fibrosis is mediated via inhibiting of AR expression.

      • KCI등재

        Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat

        Xianwei Li,Yuanyuan Shen,Yining Lu,Jieren Yang 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

        Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma is mediated by AR. Epalrestat is an aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Whether AR is involved in pathogenesis of pulmonary fibrosis and whether epalrestat attenuates pulmonary fibrosis remains unknown. Pulmonary fibrosis was induced by intratracheal instillation of bleomycin (5 mg/kg) in rats. Primary pulmonary fibroblasts were cultured to investigate the proliferation by BrdU incorporation method and flow cytometry. The expression of AR, TGF-β<sub>1</sub>, α-SMA and collagen I was analyzed by immunohis-tochemisty, real-time PCR or western blot. In vivo, epalrestat treatment significantly ameliorated the bleomycin-mediated histological fibrosis alterations and blocked collagen deposition concomitantly with reversing bleomycin-induced expression up-regulation of TGF-β<sub>1</sub>, AR, α-SMA and collagen I (both mRNA and protein). In vitro, epalrestat remarkably attenuated proliferation of pulmonary fibroblasts and expression of α-SMA and collagen I induced by TGF-β<sub>1</sub>, and this inhibitory effect of epalrestat was accompanied by inhibiting AR expression. Knockdown of AR gene expression reversed TGF-β<sub>1</sub>-induced proliferation of fibroblasts, up-regulation of α-SMA and collagen I expression. These findings suggest that AR plays an important role in bleomycin-induced pulmonary fibrosis, and epalrestat inhibited the progression of bleomycin-induced pulmonary fibrosis is mediated via inhibiting of AR expression.

      • KCI등재

        Swelling/Deswelling Self-Oscillating of Microgels Induced by the BZ Reaction with Fe(phen)3 Catalyst

        Jie Ren,Jinfen Gu,Li Tao,Guangcheng Zhang,Wu Yang 한국고분자학회 2016 Macromolecular Research Vol.24 No.6

        A novel kind of microgels, poly(NIPAAm-co-Fe(phen)3-co-AAc), were prepared by copolymerization N-isopropylacrylamide (NIPAAm), acrylic acid (AAc) and iron(II) 5-acrylamide-1,10-phenanthroline-bi(1,10-phenanthroline) (Fe(phen)3), the catalyst for the Belousov-Zhabotinsky (BZ) reaction. The microgels were characterized by FT-IR spectroscopy, X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS) and scanning electron microscope (SEM). In addition, the self-oscillating behaviors of the microgels were investigated in BZ system free of catalyst. Both the redox potential and transmittance self-oscillation were observed. Moreover, the amplitudes of poly(NIPAAm-co-Fe(phen)3-co-AAc) microgels are much larger than those of linear polymer and gel. This advantage originated from the special structure, size and composition of the microgels.

      • KCI등재

        Fabrication Tough and Electrically Conductive Graphene-Based Nanocomposite Gels with Self-Oscillating Performance

        Jie Ren,Xuemiao Wang,Aixia Zhang,Lan Zhang,Lingling Zhao,Yan Li,Wu Yang 한국고분자학회 2020 Macromolecular Research Vol.28 No.13

        Stimulus-responsive polymer gel materials were studied and applied widely in many fields in recent years. However, the poor electrically conductive property and even with poor toughness largely limit their extensive applications in more expanded fields. Herein, we report a novel kind of self-oscillating gels poly(acrylamide-coacrylic acid-co-Fe(phen)3)/reduced graphene oxide (poly(AM-co-AC-co-Fe(phen)3)/ RGO) with excellent electrical conductivity, and compressive strength via an in-situ polymerization accompanied by an ultrasonic assisted method. The dispersed reduced graphene oxide (RGO) improved the conductive and mechanical properties of the prepared materials remarkably. The conductivity of gel reached to 16.88 S·m-1 with the content of 0.34 wt% RGO and the maximum fracture pressure was 4.1 MPa, which is as high as human cartilage. Besides, the prepared gels exhibited the self-oscillating behavior in the Belousov-Zhabotinsky (BZ) solution free of catalyst. Therefore, the prepared materials have potential applications as artificial cartilage and soft electron instrument.

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