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Huanhuan Sun,Haiqing Ma,Guangyao He,Jiashu Chen,Pengxin Qiu,Guangmei Yan 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7
FIa, a factor X activator, was isolated from the venom of Daboia russellii siamensis (Myanmar) after a series of chromatographic separations. FIa displayed procoagulant activity by shortening plasma recalcification time and converted human factor X (FX) to activated human factor X (FXa) by cleaving the heavy FX chain, possibly at the Arg51-Ile52 peptide. FIa was positive in a glycoprotein staining test, demonstrating that it is a glycoprotein. Optimal temperature and pH values were important for FIa procoagulant activity. Procoagulant activity was maintained above 85% of the initial activity at pH 7.0~8.0, and showed equally maximum activity at temperatures ranging from 30 to 50oC. In addition, FIa procoagulant activity was completely inhibited by EDTA (5 mM), but not by PMSF (10 mM), suggesting that it is a metalloproteinase.
Zhang, Lu,Feng, Qiang,Wang, Jiuling,Zhang, Shuai,Ding, Baoquan,Wei, Yujie,Dong, Mingdong,Ryu, Ji-Young,Yoon, Tae-Young,Shi, Xinghua,Sun, Jiashu,Jiang, Xingyu American Chemical Society 2015 ACS NANO Vol.9 No.10
<P>The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and <I>in vivo</I> stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell–particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell–particle interaction may have important implications for designing drug nanocarriers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-10/acsnano.5b05792/production/images/medium/nn-2015-05792e_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b05792'>ACS Electronic Supporting Info</A></P>