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RISS 인기검색어
- 검색키워드
- 저자 : Jiahao Hu (검색결과 5 건)
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Analyzing green view index and green view index best path using Google street view and deep learning
Zhang Jiahao,Hu Anqi 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.5
As an important part of urban landscape research, analyzing and studying street-level greenery can increase the understanding of a city’s greenery, contributing to better urban living environment planning and design. Planning the best path of urban greenery is a means to effectively maximize the use of urban greenery, which plays a positive role in the physical and mental health of urban residents and the path planning of visitors. In this paper, we used Google street view to obtain street view images of Osaka City. The semantic segmentation model is adopted to segment the street view images and analyze the green view index (GVI) of Osaka City. Based on the GVI, we take advantage of the adjacency matrix and Floyd–Warshall algorithm to calculate GVI best path, solving the limitations of ArcGIS software. Our analysis not only allows the calculation of specific routes for the GVI best paths but also realizes the visualization and integration of neighborhood urban greenery. By summarizing all the data, we can conduct an intuitive feeling and objective analysis of the street-level greenery in the research area. Based on this, such as urban residents and visitors can maximize the available natural resources for a better life. The dataset and code are available at https://github.com/Jackieam/GVI-Best-Path.
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Quantum Coherent Dissociation in a Hybrid Atom-light System with Photon Loss
Xiaoyang Yuan,Jialu Yin,Jiahao Xu,Yixiao Huan,Zhengda Hu 한국광학회 2024 Current Optics and Photonics Vol.8 No.1
We investigate the effect of photon loss on pair production in a hybrid atom-light system. The loss of light field not only affects the generation of photons, but also prevents the generation of atomic collective excitation, although the atoms are not influenced directly. We propose an unbalanced homodyne detection of the number of atomic collective excitation that overcomes the challenge caused by counting uncertainty in practical measurement. In discussion, we show that the intermode correlations and the number correlation is closely related to the initial input state, while the quadrature correlations are independent of the initial state and always exhibit opposite intermode correlations even in the presence of loss.
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Fulin Wang,Qi Tao,Luoqiong Xiao,Jiahao Hu,Leilei Xu 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.5
A realistic finite element model considering the ploughing effect of cutting edge fillet was developed in high speed machining. Taking the hardened tool steel AISI D2 as the object of research, the cutting force and chip morphology were reasonably analyzed and compared with the actual results of cutting experiments, which verified the correctness of the model. Then, based on the model, the formation process of single serrated tooth was analyzed, while the effects of cutting heat and temperature field, material hardness and cutting speed on chip formation were explored. The research results indicate that: (1) The ploughing-effect has a great impact on the feed force, and for hardened tool steel AISI D2, the stagnation angle of 30 o is more appropriate. (2) Also, stress concentration appears and shear slipping occurs along the shear plane in the process of serrated chip formation. The strain rate on the shear slipping surface is much greater than other places and the temperature gradient perpendicular to the shear plane is relatively higher. (3) The cutting force becomes larger with increasing the hardness value of workpieces, which causes the chip to more likely to produce serrated chips. (4) The fluctuation of cutting force is more significant as the cutting speed increases, which puts forward higher requirements for the tool and machine tool.
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Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate
Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.
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Chunping Yu,Yi Zhang,Ning Wang,Wensu Wei,Ke Cao,Qun Zhang,Peiying Ma,Dan Xie,Pei Wu,Biao Liu,Jiahao Liu,Wei Xiang,Xing Hu,Xuewen Liu,Jianfei Xie,Jin Tang,Zhi Long,Long Wang,Hongliang Zeng,Jianye Liu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.1
Background: Circular RNAs (circRNAs) have important functions in many fields of cancer biology. In particular, we previously reported that the oncogenic circRNA, circPRMT5, has a major role in bladder cancer progression. Therapy based on circRNAs have good prospects as anticancer strategies. While anti-circRNAs are emerging as therapeutics, the specific in vivo delivery of anti-circRNAs into cancer cells has not been reported and remains challenging. Methods: Synthesized chrysotile nanotubes (SCNTs) with a relatively uniform length (~ 200 nm) have been designed to deliver an siRNA against the oncogenic circPRMT5 (si-circPRMT5) inhibit circPRMT5. In addition, the antitumor effects and safety evaluation of SCNTs/si-circPRMT5 was assessed with a series of in vitro and in vivo assays. Results: The results showed that SCNTs/si-circPRMT5 nanomaterials prolong si-circPRMT5’s half-life in circulation, enhance its specific uptake by tumor cells, and maximize the silencing efficiency of circPRMT5. In vitro, SCNTs encapsulating si-circPRMT5 could inhibit bladder cancer cell growth and progression. In vivo, SCNTs/si-circPRMT5 inhibited growth and metastasis in three bladder tumor models (a subcutaneous model, a tail vein injection lung metastatic model, and an in situ model) without obvious toxicities. Mechanistic study showed that SCNTs/sicircPRMT5 regulated the miR-30c/SNAIL1/E-adherin axis, inhibiting bladder cancer growth and progression. Conclusion: The results highlight the potential therapeutic utility of SCNTs/si-circPRMT5 to deliver si-circPRMT5 to treat bladder cancer.
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