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Nontraditional Therapies to Treat Helicobacter pylori Infection
Morris O. Makobongo,D. Scott Merrell,Jeremy J. Gilbreath 한국미생물학회 2014 The journal of microbiology Vol.52 No.4
The Gram-negative pathogen Helicobacter pylori is increasinglymore resistant to the three major antibiotics (metronidazole,clarithromycin and amoxicillin) that are most commonlyused to treat infection. As a result, there is an increasedrate of treatment failure; this translates into an overall highercost of treatment due to the need for increased length of treatmentand/or the requirement for combination or sequentialtherapy. Given the rise in antibiotic resistance, the complicatedtreatment regime, and issues related to patient compliancethat stem from the duration and complexity of treatment,there is clearly a pressing need for the development ofnovel therapeutic strategies to combat H. pylori infection. As such, researchers are actively investigating the utility ofantimicrobial peptides, small molecule inhibitors and naturopathictherapies. Herein we review and discuss each ofthese novel approaches as a means to target this importantgastric pathogen.