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최완재(Wanjae Choi),류현일(Hyunil Ryu),고슬미니(Seulmini Goh),주조가(Chaoge Zhou),권순조(Soonjo Kwon),전태준(Tae-Joon Jeon),김선민(Sun Min Kim) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12
Local anesthetics convert into cations in the body and bind to specific receptors in the sodium ion channel in the cell membrane to prevent the inflow of sodium ions and prevent cell membrane potential changes. This results in no neuronal transmission of the cells. Local anesthetics have been used to treat pain after surgery or through postoperative pain. However, local anesthetics can cause fatal side effects to prevent neurotransmission. It also changes heart rate, stimulates the central nervous system to give a sense of helplessness or delay breathing. The toxicity of these local anesthetics does not only affect the membrane protein, but also has a direct effect on the biomembrane. Toxicity studies applied to membrane proteins have been carried out so far, but toxicity studies applied to biomembranes have not progressed much. SEM photographs of the cells confirmed that the cells have an effect on the biomembrane and IC50 confirmed the cytotoxicity of lidocaine and tetracaine. Artificial cell membrane were prepared with a black lipid bilayer incorporating gramicidin and polydiacetylene (PDA), and the effects of local anesthetics on the biomembrane were quantitatively measured. These measurements can be used to measure the biomembrane toxicity of other local anesthetics and new local anesthetic agents.
복합 규칙성을 가진 구조물의 효과적인 해석을 위한 다단계 균질화기반 해석 프레임워크
전영재,장완재,장성민,Youngjae Jeon,Wanjae Jang,Seongmin Chang 한국전산구조공학회 2023 한국전산구조공학회논문집 Vol.36 No.1
전산 자원의 발달로 여러 부품들이 결합된 전체 구조물에 대한 해석이 가능해져 해석에 필요한 계산 시간과 데이터의 양이 증가하였다. 이러한 전체 구조물에는 같은 부품이 반복되어 규칙성을 가지는 경우가 많다. 이러한 반복적인 구조물에 균질화 기법을 적용하면 효과적인 해석이 가능하다. 상용 프로그램의 일반적인 균질화 모듈에서 단위 구조는 모든 방향으로 반복된다고 가정한다. 하지만 실제 구조물들은 여러 단위 구조가 복잡하게 반복되는 경우가 많아 기존 균질화 기법을 적용하는데 어려움이 있다. 본 논문에서는 복잡한 반복성을 고려하는 다단계 균질화 기법을 제안한다. 제안된 균질화 기법은 구조물을 여러 영역으로 나누어 균질화를 수행하는 형태로 기존 기법보다 정확한 해석이 가능하다. Because of the development of computational resources, an entire structure in which many components are combined can be analyzed. To do so, the calculation time and number of data points are increased. In many practical industry structures, there are many parts with repeated patterns. To analyze the repetitive structures effectively, a homogenization method is usually employed. In a homogenization module, including commercial programs, it is generally assumed that a unit cell is repeated in all directions. However, the practical industry structures usually have complicated, repeated patterns or structures. Complicated patterns are difficult to address using the conventional homogenization method. Therefore, in this study, a multilevel homogenization method was devised to consider complex regularities. The proposed homogenization method divides the structure into several areas and performs multiple homogenizations, resulting in a more accurate analysis than that provided by the previous method.
STRAIN RATE CHANGE FROM 0.04 TO 0.004%/S IN ANENVIRONMENTAL FATIGUE TEST OF CF8M CASTSTAINLESS STEEL
ILL-SEOK JEONG,WANJAE KIM,김태룡,HYUN-IK JEON 한국원자력학회 2011 Nuclear Engineering and Technology Vol.43 No.1
To define the effect of strain rate variation from 0.04% to 0.004%/s on environmental fatigue of CF8M cast stainlesssteel, which is used as a primary piping material in nuclear power plants, low-cycle fatigue tests were conducted at operatingpressure and temperature condition of a pressurized water reactor, 15 MPa and 315ºC, respectively. A high-pressure andhigh-temperature autoclave and cylindrical solid fatigue specimens were used for the strain-controlled low-cycle environmentalfatigue tests. It was observed that the fatigue life of CF8M stainless steel is shortened as the strain rate decreases. Due to theeffect of test temperature, the fatigue data of NUREG-6909 appears a slightly shorter than that obtained by KEPRI at thesame stress amplitude of 1x103MPa. The environmental fatigue correction factor Fen’s calculated with inputs of the test dataincreases with high strain amplitude, while the Fen’s of NUREG-6909 remain constant regardless of strain amplitude.