http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Survey on Current Status of Laboratory Animals for Establishing New National Policy
Seung Wan Jee,Dae Youn Hwang,Chuel Kyu Kim,Yong Kyu Kim,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Yoon Mi Hwang,Jin Hee Park,Hyun-Gu Kang,Jung Sik Cho 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
Facility maintenance for laboratory animals are critical and fundamental for obtaining the trustable results on the animal experiment and health science. The aim of this study was to survey the current situation of the animals facility in Korea. To do this, a total of 223 institutions having laboratory animals was chosen for search their general current situations on the institution's facility, facility equipment, and the environment of animal facility. Herein, the animals facilities were mainly had the small size of concrete structure, and the BSL facility was slightly increased. But, many facilities were only controlled the humidity and temperature in the animal breeding room. We concluded that the levels of animal facilities were extremely low spite of increasing of animal users, and thereby recognizing necessity of support at the national level.
알츠하이머 형질전환 마우스의 출생 후 뇌에서 유전자 발현
지승완(Seung Wan Jee),송연숙(Youn Suk Song),오재호(Jae Ho Oh),김용규(Yong Kyu Kim),심선보(Sun Bo Shim),황대연(Dae Youn Hwang),이수해(Su Hae Lee),서수진(Su Jin Seo),조준용(Jun Yong Cho),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
DNA microarrays are a well-established technology for measuring gene expression levels. The aim in the study was to gain insight into potential over-expressed effect of amyloid precursor protein sw (APPsw) on modulation of genes for Alzheimer's Disease (AD). APPsw-transgenic mice, which has been produced by us previously, provide an important resource for identifying differentially expressed genes, since this transgenic line was shown cognitive deficits along with Aβ-42 depositions at 12 months of age. Using cDNA microarray, we compared mRNA levels in 7.4K cDNA clones from postnatal brain of age-matched wild-type mice and Alzheimer's diseased transgenic mice. A total of 44 differentially expressed genes with a 15 up-regulated and with a 29 down-regulated were found in brains from moderatively transgenic mice compared to non-transgenic littermates. Thus, the results allow to the future studies in the functions of each gene, which may be targeted for developing drugs.
인간 간세포에서 C형 간염 바이러스의 replicase발현
지승완,유병제 대구대학교 기초과학연구소 1998 基礎科學硏究 Vol.15 No.1
To analyze the RdRp in eukaryotic HuH7 cells transfected defective HCV RNAs, cotransfection of defective HCV RNAs and defective HCV-CAT negative RNAs that had the essential portion of HCV for replication and translation, and CAT as reporting gene was performed. In cells transfected with defective HCV RNA and negative HCV-CAT RNA, the amount of CAT was quantified by Chloramphenicol acetyl transferase(CAT) enzyme-linked immunosorbent assay(ELISA). The NS5b of HCV was expressed from defective HCV 14H RNA and had a activity of RdRp. And, the defective HCV RNA and defective negative HCV-CAT RNA were replicated without other viral factors.
지승완,유병제 大邱大學校附設 基礎科學硏究所 1998 基礎科學硏究 Vol.15 No.1
Hepatitis C virus (HCV) is the major causative agent of posttransfusion and sporadic non-A, non-B hepatitis. To time, many research for HCV have been performed, but the molecular mechanism of HCV replication is still not obvious. To define the essential region of HCV genome for replication and develop the RNA-dependent RNA polymerase(RdRp) of HCV assay system in vivo. I constructed defective HCV cDNA that contained 5'Untranslate reagion,(UTR), Core(C), Enveloper 1(4 amino adds), Nonstructure(NS)5b, and various 3'UTR.
지승완,유병제 大邱大學校附設 基礎科學硏究所 1998 基礎科學硏究 Vol.15 No.1
The cells transfected with defective HCV RNAs alone, were harvested at various days after transfection. The replication of various defective HCV RNAs was checked by the quantification of HCV RNAs in transfected cell. The amount of HCV RNAs were estimated by the chiron bDNA kit. All the case, the amounts of HCV RNAs in transfected cells were decreased.