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        Numerical desirability function for adsorption of methylene blue dye by sulfonated pomegranate peel biochar: Modeling, kinetic, isotherm, thermodynamic, and mechanism study

        Ali H. Jawad,Ahmed Saud Abdulhameed,M. A. K. M. Hanafiah,Zeid A. AlOthman,Mohammad Rizwan Khan,S. N. Surip 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.7

        Sulfonated pomegranate (Punica granatum) peel biochar (SPPBC) was developed via thermal activation with sulfuric acid (H2SO4) to act as a promising biochar material for the adsorptive removal of toxic cationic dye namely methylene blue (MB) dye from contaminated water. A Box-Behnken design (BBD) and numerical desirability function were adopted to optimize the input adsorption variables (SPPBC dosage, temperature, pH, and contact time). The maximum removal of the MB dye can be accomplished by simultaneous significant interaction between SPPBC dosage with solution pH, SPPBC dosage with time, SPPBC dosage with temperature, solution pH with time, and time with temperature. The numerical desirability function identified the highest MB dye removal (93.9%) can be achieved at the following optimum numerical adsorption conditions: SPPBC dosage 0.18 g, temperature 49 oC, pH 9.7, and time 4.3 h. Equilibrium data were well fitted to the Temkin and Langmuir isotherm models. The maximum recorded adsorption capacity of SPPBC for MB dye adsorption by using Langmuir isotherm model was 161.9mg/g. This research work reveals the possibility of converting lignocellulose pomegranate peel into a renewable and environmentfriendly biochar via a relatively fast acid-activation process with the great potential to be promising adsorbent for removal of MB dye.

      • Fault-Aware Dual-Layer Adaptive Error Control Technique for NoC

        Waqar Amin,Naveed Khan Baloch,Jawad Ali Khan,Muhammad Iram Baig 한국산학기술학회 2015 SmartCR Vol.5 No.6

        The network-on-a-chip (NoC) appeared as a promising solution to handle the communications requirements of the multiprocessor system-on-a-chip (MPSoC). As the complexity of designs rises and the technology scales down into the deep-submicron domain, the probability of errors in the NoC components increases. Fault tolerance is a vital aspect in designing NoC architectures for future MPSoCs. This paper proposes an adaptive fault-tolerant technique that is a hybrid end-to-end and hop-to-hop, offering benefits of both error control schemes, and introduces a fault-aware adaptive selective hop-to-hop error correction scheme. The proposed technique ensures improvement in reliability by reducing the latency of the network in low transient–noise conditions.

      • Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents

        Atiq, Ayesha,Shal, Bushra,Naveed, Muhammad,Khan, Adnan,Ali, Jawad,Zeeshan, Sara,Al-Sharari, Shakir D.,Kim, Yeong Shik,Khan, Salman Elsevier 2019 european journal of pharmacology Vol.843 No.-

        <P><B>Abstract</B></P> <P>5-Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent. However, its use is associated with several debilitating adverse effects such as intestinal mucositis (IM) and myelosuppression. Oxidative stress and inflammation are major contributors in the development of mucositis. Diadzein is known for its potent anti-inflammatory and anti-oxidative activities from decades. The present study focused on investigating the effects of diadzein on intestinal mucositis induced by 5-FU by mainly focusing on oxidative stress and inflammatory markers in mice. Mucositis was induced in mice by administration of 5-FU (50 mg/kg, i.p.), once daily for three days and diadzein (1, 5, 10 mg/kg) was administered once daily for seven days. Diadzein pretreatment was found to reduce the severity of mucosal injury in a dose-dependent manner. Diadzein significantly reversed weight loss, relieved diarrhea, and improved histopathological deformities associated with inflammation. Moreover, diadzein remarkably improved the intestinal wall histopathology by reducing inflammatory mediators infiltration and prevented suppression of antioxidants (glutathione, glutathione sulfo-transferase, and catalase) by 5-FU administration. Furthermore, nitrite production in intestinal tissue was reduced by diadzein consistent with the observed modulation of inflammatory markers. Additionally, diadzein also improved the amended microflora profile, by reducing the number of pathogenic bacteria and increasing the abundance of probiotics. Taken together, the behavioral, biochemical and histological outcomes of the present study demonstrates that diadzein has significant anti-mucositis properties in 5-FU induced mucositis model, and the attenuative potential of diadzein might be due to inhibition of oxidative stress and inflammatory mediators.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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