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- 저자 : Janaina Coser (검색결과 1 건)
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Thaís da Rocha Boeira,Janaina Coser,Jonas Michel Wolf,Bruna Klahr Manggini Cardinal,Ivana Grivicich,Daniel Simon,Vagner Ricardo Lunge 대한암예방학회 2018 Journal of cancer prevention Vol.23 No.3
Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression ofan HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53, NQO1 andRPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North Americanpopulations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809with CC in an admixed population in southern Brazil. A total of 435 women (106 CC patients and 329 controls) were recruited forthis study. All women were interviewed and underwent clinical sampling. SNPs rs1042522 and rs1800566 were evaluated by PCR-RFLP. SNP rs2305809 was determined by real-time PCR. The crude and adjusted ORs with 95% CI were estimated. The recessive genetic model(C/C + C/T) for rs2305809 was more frequent in the control group (79.9%) compared to the cases (69.8%), being associated withCC protection (adjustedOR = 0.49; 95% CI: 0.27-0.90). However, the other polymorphisms evaluated did not present significant differencesbetween cases and controls. This study detected a protective association for the recessive genetic model in rs2305809. These resultssuggest a potential role of the RPS19 gene in CC.
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