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Carbon nanotubes as drug delivery nanocapsules
Tamsyn A. Hilder,James M. Hill 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
Nanotubes have been proposed as targeted drug delivery nanocapsules which may realize the ‘‘magic bullet’’ concept and promisemany advantages over current procedures. The question arises as to whether a nanotube drug carrier could be engineered so that itis energetically favourable for the drug molecule to be encapsulated, and then once inside the cell, energetically favourable to be ejected.In other words, we need to understand and accurately predict the uptake and expulsion capacities of a particular carbon nanotube inand the suction energy are used to determine the suction behaviour of cisplatin, a platinum-based anticancer drug. It is shown theoret-ically using elementary mechanics and applied mathematical modelling techniques that for cisplatin to be accepted, the carbon nanotubemust have a radius of at least 4.785 Å, and that the maximum suction energy occurs when the carbon nanotube radius is 5.27 Å.
Spherical and spheroidal fullerenes entering carbon nanotubes
Barry J. Cox,Ngamta Thamwattana,James M. Hill 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
A continuous model of a fullerene inside a carbon nanotube and for which both the fullerene and carbon nanotube are treated assmooth surfaces with uniform atomic number densities and the van der Waals interaction is formulated using a 612 Lennard-Jonespotential. From the model we derive acceptance conditions and suction energies for C60,C70 and C80 fullerenes. We show that for thesesystems where the fullerenes are not accepted by the nanotube, then the suction energy is particularly sensitive to the equatorial semi-axislengthb. Alternatively, when the nanotube does accept the fullerene then an approximately equal suction energy per atom is obtained forall the fullerene types with little or no sensitivity to change in the equatorial semi-axis length. The analysis is given for the spherical ful-lerene C60 for which good agreement with molecular dynamics studies is obtained and it is repeated for C70 and C80 fullerenes using aself-consistent solution.
Predicting particle transport through an aging polymer using vacancy diffusion
Aaron W. Thornton,Anita J. Hill,Kate M. Nairn,James M. Hill 한국물리학회 2008 Current Applied Physics Vol.8 No.3,4
Understanding the process of particle transport is important for various applications such as separation, storage and blockage ofselected particles within a polymer. The diusivity of particles has been related to the fractional free volumefwithin a sample by theexpressionD(f)=A exp(. B/f A and B.Polymers are known to undergo physical aging such that the free volumedistribution changes over time towards an equilibrium. This phenomenon has been well explained by the vacancy diusion model estab-lished by Curro et al. [J.G. Curro, R.R. Lagasse, R. Simha, Macromolecules 15 (1982) 1621]. Using both the diusion expression and thevacancy diusion model, this paper models particle transport in aging, unaged and aged polymer samples.