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Jain Koo,Seohyun Lee,Sooho Yeo,김도현,Minwoo Park,Tack Soo Nam,이재휘 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.3
Herein we investigate the influence of hydrophilic polymers on the buccal permeability of collagen hydrolysate (CGH) by performing in vitro buccal permeation test and viscosity measurements. After we demonstrated that CGH (2000?3000?Da) could be delivered across the reconstructed human buccal tissue as evaluated by hydroxyproline assay, the effects of different hydrophilic polymers, varying amounts of CGH, and hydration methods were examined to elucidate the relationship with buccal permeation behavior of CGH. The percentage of CGH permeated was found to be highest in HPMC E5 solution and greater when the viscosity of test solutions was low. Using commercially obtained CGH-loaded buccal films, the films under higher hydration condition exhibited greater CGH permeation. This study demonstrates that CGH can be delivered via the human buccal tissue and viscosity of the solution significantly affects the CGH permeation. These findings are valuable for designing hydrophilic polymer-based buccal film formulations for peptides like CGH.
Jain, Rishabh,Singh, Yashpal,Cho, Soo-Yeon,Sasikala, Suchithra Padmajan,Koo, Sung Hwan,Narayan, Rekha,Jung, Hee-Tae,Jung, Yousung,Kim, Sang Ouk American Chemical Society 2019 Chemistry of materials Vol.31 No.8
<P>Phosphorene suffers from instability under ambient condition, despite its potential to bridge the gap between graphene and two-dimensional (2D) metal chalcogenides. We report effective exfoliation and stabilization of few layer phosphorene (FLP) in the presence of strongly interacting surfactants. Surfactants containing long hydrophobic chain and nonbulky charged headgroups (CTAB) effectively exfoliate and stabilize FLP in water, which is consistent with our density functional theory prediction. Nuclear magnetic resonance measurements are systematically employed to probe the interaction between surfactants and FLP. Retarded diffusion rate measured by 2D DOSY spectroscopy revealed the presence of noncovalently bonded CTAB over phosphorene. 2D NOESY spectroscopy further suggests the interdigitated arrangement of surfactants. Such a tight interaction impedes the ambient degradation rate of phosphorene by 70-80%. This work proposes a new insight into the control over ambient degradation of phosphorene without altering its intrinsic properties.</P> [FIG OMISSION]</BR>
Nanomedicine approaches for medulloblastoma therapy
Lim Chaemin,Koo Jain,오경택 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.2
Background Over the past 30 years, brain tumors have been intensively studied with a variety of therapeutic approaches. However, brain cancer is still one of the most lethal forms of cancer, and the mortality rates have still not significantly improved. Since the late 2010s, transcriptomic analysis of medulloblastoma (MB), the most malignant pediatric brain tumor, has been actively conducted. These efforts have facilitated classification of MB into specific subgroups, enabling more molecularly targeted therapies. However, from a pharmaceutical standpoint, there is one more hurdle to overcome, which is the blood-brain barrier (BBB). Area Covered In this review, we provide information on the characteristics of each subgroup of MB and a list of Food and Drug Administration (FDA)-approved drugs or drugs in clinical trials used for the treatment of this disease. In addition, we introduce lists of methods that can overcome the BBB, a major hurdle for MB treatment, by applying nanotechnology. Finally, we provide a general overview of the state of nanomedicine for brain tumors. Expert Opinion Various types of nanotechnologies have been extensively studied and have shown clear advantages for treatment of brain tumors. However, despite the exploration of these various nanoparticles in preclinical studies, the types of nanoparticles evaluated in clinical trials are very limited, and a number of clinical trial failures have also occurred. Therefore, further insights into relevant regulations as well as rational design of nanoparticles for improved reproducibility are required to bridge the gap between preclinical and clinical studies.
Kim Dohyun,Shin Daehyun,Koo Jain,Kim Jungseop,Na Seon Jeong,Bang Joon Seok,Na Dong Hee,Lee Jaehwi 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.6
This study aimed to investigate the effects of various factors, including contact time, disk shape, and polymer molecular weight, on the in vitro mucoadhesive properties of disks prepared using hydrophilic polymers. Mucoadhesive performance was evaluated by measuring the peak detachment force and work of adhesion values using tensile tests. The mucoadhesive force and work of adhesion values increased with increasing contact time between the polymeric disks and mucin gel layer until 60 s. Increased mucoadhesive performances were typically observed when the disks comprised high-molecular-weight polymers, which indicates the increase in the entanglement. Increasing the thicknesses of the disks allowed the disks to absorb more water and thereby have more flexible polymeric chains, enhancing the mucoadhesive capacity. The proportional increase in the mucoadhesive force and work values were observed with increasing the surface areas of the disks. In conclusion, this study comprehensively demonstrated the effects of various experimental factors on mucoadhesion.
미세 플라스틱 측정을 위한 MEMS 기반 미세유체 구조와 고주파 전송특성을 이용한 전극이 결합된 센서 연구
김진형(JinHyoung Kim),이권홍(Kwonhong Lee),신규식(Kyusik Shin),김상식(Sangsik Kim),구승현(Seunghyeon Koo),최자인(Jain Choi),차철웅(Cheolung Cha) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6
Recently, as environmental problems have grown, and among them, fine particles such as fine dust/fine plastic have become a problem, research on fine particle sensors is being actively conducted. In previous studies, the form of simply concentrating fine particles at a high concentration and putting them into a trapping space for measurement was used, and sensors with a structure of reading changes in S-parameters, especially reflection coefficient (S11), at a specific frequency using LC resonance were proposed. This form is not favorable for measuring fine particles that exist in extremely low concentrations in real-life environments. While the structure of reading reflection coefficient (S11) may be convenient for reading with commercial measurement equipment such as a Network Analyzer, it is advantageous to read transmission coefficient (S21) for commercialization. In this study, we captured lowconcentration fine particles dispersed in liquid using MEMS-based microfluidics and filter structures, thereby improving the sensitivity. Additionally, we designed the sensor to read transmission coefficient (S21) instead of reflection coefficient (S11) to increase commercial feasibility. As a result, we designed a fine particle measurement sensor with a center frequency of 1.2 GHz, and confirmed that the frequency shifted from 1.2028 GHz to 1.1929 GHz by inputting microplastics (PE).