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Jafary, Fariba,Salehi, Mansoor,Sedghi, Maryam,Nouri, Nayereh,Jafary, Farzaneh,Sadeghi, Farzaneh,Motamedi, Shima,Talebi, Maede Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.
Abolfazl Jafari Natanzi,Gholamreza Soleimani Jafari,Reza Kolahchi 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.5
In this study, nonlinear vibration and stability of a polymeric pipe reinforced by single-walled carbon naotubes (SWCNTs) conveying fluid-nanoparticles mixture flow is investigated. The Characteristics of the equivalent composite are determined using Mori-Tanaka model considering agglomeration effects. The surrounding elastic medium is simulated by orthotropic visco-Pasternak medium. Employing nonlinear strains-displacements, stress-strain energy method the governing equations were derived using Hamilton's principal. Differential quadrature method (DQM) is used for obtaining the frequency and critical fluid velocity. The influence of volume percent of SWCNTs, agglomeration, geometrical parameters of pipe, viscoelastic foundation and fluid velocity are shown on the frequency and critical fluid velocity of pipe. Results showed the increasing volume percent of SWCNTs leads to higher frequency and critical fluid velocity.
Trends of Breast Cancer Incidence in Iran During 2004-2008: A Bayesian Space-time Model
Jafari-Koshki, Tohid,Schmid, Volker Johann,Mahaki, Behzad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background: Breast cancer is the most frequently diagnosed cancer in women and estimating its relative risks and trends of incidence at the area-level is helpful for health policy makers. However, traditional methods of estimation which do not take spatial heterogeneity into account suffer from drawbacks and their results may be misleading, as the estimated maps of incidence vary dramatically in neighboring areas. Spatial methods have been proposed to overcome drawbacks of traditional methods by including spatial sources of variation in the model to produce smoother maps. Materials and Methods: In this study we analyzed the breast cancer data in Iran during 2004-2008. We used a method proposed to cover spatial and temporal effects simultaneously and their interactions to study trends of breast cancer incidence in Iran. Results: The results agree with previous studies but provide new information about two main issues regarding the trend of breast cancer in provinces of Iran. First, this model discovered provinces with high relative risks of breast cancer during the 5 years of the study. Second, new information was provided with respect to overall trend trends o. East-Azerbaijan, Golestan, North-Khorasan, and Khorasan-Razavi had the highest increases in rates of breast cancer incidence whilst Tehran, Isfahan, and Yazd had the highest incidence rates during 2004-2008. Conclusions: Using spatial methods can provide more accurate and detailed information about the incidence or prevalence of a disease. These models can specify provinces with different health priorities in terms of needs for therapy and drugs or demands for efficient education, screening, and preventive policy into action.
Jafari, Hamid Reza,Seifbarghy, Mehdi Korean Institute of Industrial Engineers 2016 Industrial Engineeering & Management Systems Vol.15 No.4
The efficiency of a supply chain can be extremely affected by its design which includes determining the flow pattern of material from suppliers to costumers, selecting the suppliers, and defining the opened facilities in network. In this paper, a multi-objective multi-echelon multi-product supply chain design model is proposed in which several suppliers, several manufacturers, several distribution centers as different stages of supply chain cooperate with each other to satisfy various costumers' demands. The multi-objectives of this model which considered simultaneously are 1-minimize the total cost of supply chain including production cost, transportation cost, shortage cost, and costs of opening a facility, 2-minimize the transportation time from suppliers to costumers, and 3-maximize the service level of the system by minimizing the maximum level of shortages. To configure this model a graph theoretic approach is used by considering channels among each two facilities as links and each facility as the nodes in this configuration. Based on complexity of the proposed model a multi-objective Pareto-based vibration damping optimization (VDO) algorithm is applied to solve the model and finally non-dominated sorting genetic algorithm (NSGA-II) is also applied to evaluate the performance of MOVDO. The results indicated the effectiveness of the proposed MOVDO to solve the model.
REMARKS ON THE INNER POWER OF GRAPHS
JAFARI, S.,ASHRAFI, A.R.,FATH-TABAR, G.H.,TAVAKOLI, Mostafa The Korean Society for Computational and Applied M 2017 Journal of applied mathematics & informatics Vol.35 No.1
Let G be a graph and k is a positive integer. Hammack and Livesay in [The inner power of a graph, Ars Math. Contemp., 3 (2010), no. 2, 193-199] introduced a new graph operation $G^{(k)}$, called the $k^{th}$ inner power of G. In this paper, it is proved that if G is bipartite then $G^{(2)}$ has exactly three components such that one of them is bipartite and two others are isomorphic. As a consequence the edge frustration index of $G^{(2)}$ is computed based on the same values as for the original graph G. We also compute the first and second Zagreb indices and coindices of $G^{(2)}$.
Jafari, Ehsan,Marjanian, Ali,Solaymani, Soodabeh,Shahgholian, Ghazanfar The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.3
The controllability and stability of power systems can be increased by Flexible AC Transmission Devices (FACTs). One of the FACTs devices is Interline Power-Flow Controller (IPFC) by which the voltage stability, dynamic stability and transient stability of power systems can be improved. In the present paper, the convenient operation and control of IPFC for transient stability improvement are considered. Considering that the system's Lyapunov energy function is a relevant tool to study the stability affair. IPFC energy function optimization has been used in order to access the maximum of transient stability margin. In order to control IPFC, a Brain Emotional Learning Based Intelligent Controller (BELBIC) and PI controller have been used. The utilization of the new controller is based on the emotion-processing mechanism in the brain and is essentially an action selection, which is based on sensory inputs and emotional cues. This intelligent control is based on the limbic system of the mammalian brain. Simulation confirms the ability of BELBIC controller compared with conventional PI controller. The designing results have been studied by the simulation of a single-machine system with infinite bus (SMIB) and another standard 9-buses system (Anderson and Fouad, 1977).
Jafari, Naser,Zargar, Seyed Jalal,Yassa, Narguess,Delnavazi, Mohammad Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Objective: Dorema glabrum Fisch. & C.A. Mey is a perennial plant that has several curative properties. Anti-proliferative activity of seeds of this plant has been demonstrated in a mouse fibrosarcoma cell line. The aim of the present study was to evaluate cytotoxicity of D. glabrum root extracts in a human gastric adenocarcinoma (AGS) cell line and explore mechanisms of apoptosis induction, cell cycle arrest and altered gene expression in cancer cells. Materials and Methods: The MTT assay was used to evaluate IC50 values, EB/AO staining to analyze the mode of cell death, and flow cytometry to assess the cell cycle. Quantitative real-time polymerase chain reaction (qRT-PCR) amplification was performed with apoptosis and cell cycle-related gene primers, for cyclin D1, c-myc, survivin, VEGF, Bcl-2, Bax, and caspase-3 to determine alteration of gene expression. Results: Our results showed that n-hexane and chloroform extracts had greatest toxic effects on gastric cancer cells with IC50 values of $6.4{\mu}g/ml$ and $4.6{\mu}g/ml$, respectively, after 72 h. Cell cycle analysis revealed that the population of treated cells in the G1 phase was increased in comparison to controls. Cellular morphological changes indicated induction of apoptosis. In addition, mRNA expression levels of Bax and caspase-3 were increased, and of bcl-2 survivin, VEGF, c-myc and cyclin D1 were decreased. Conclusion: Our study results suggest that D. glabrum has cytotoxic effects on AGS cells, characterized by enhanced apoptosis, reduced cell viability and arrest of cell cycling.
Jafari, Mohammad,Jung, Jongwon Hindawi Limited 2018 Geofluids Vol.2018 No.-
<P>Geological CO2 sequestration has been proposed as an effective solution to mitigate excessive human-emitted CO2 in atmosphere. Knowledge of immiscible two-phase flow of CO2-water/brine is necessary to evaluate the efficiency and safety of geological storage sites. Among forces dominating fluid flow, capillary pressure is highly important because of high uncertainty in measurement due to ambiguous wettability behavior of geomaterials. In particular, time-dependent wettability of geomaterials is of interest for predicting short-term performance of the storage site. After injection of CO2 into an aquifer, both the CO2 and water/brine in rocks pores are unsaturated and tend to dissolve into each other. Present study investigates the variation of contact angle on mica sheet using a captive bubble method at a wide range of pressures and salinities under unsaturated condition. Our results showed a general increase of contact angle with time. Comparison of unsaturated contact angle with previous results in the literature showed a wide span of wettability behavior, ranging from receding to advancing contact angle values reported in the literature. The observed decrease in wettability by time due to heterogeneity and pinning effect of triple line can jeopardize the safety of geological carbon sequestration projects in short-term after injection of CO2.</P>