Association between Mismatch Repair Gene MSH3 codons 1036 and 222 Polymorphisms and Sporadic Prostate Cancer in the Iranian Population

Jafary, Fariba,Salehi, Mansoor,Sedghi, Maryam,Nouri, Nayereh,Jafary, Farzaneh,Sadeghi, Farzaneh,Motamedi, Shima,Talebi, Maede Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

The mismatch repair system (MMR) is a post-replicative DNA repair mechanism whose defects can lead to cancer. The MSH3 protein is an essential component of the system. We postulated that MSH3 gene polymorphisms might therefore be associated with prostate cancer (PC). We studied MSH3 codon 222 and MSH3 codon 1036 polymorphisms in a group of Iranian sporadic PC patients. A total of 60 controls and 18 patients were assessed using the polymerase chain reaction and single strand conformational polymorphism. For comparing the genotype frequencies of patients and controls the chi-square test was applied. The obtained result indicated that there was significantly association between G/A genotype of MSH3 codon 222 and G/G genotype of MSH3 codon 1036 with an increased PC risk (P=0.012 and P=0.02 respectively). Our results demonstrated that MSH3 codon 222 and MSH3 codon 1036 polymorphisms may be risk factors for sporadic prostate cancer in the Iranian population.

Vibration and instability of nanocomposite pipes conveying fluid mixed by nanoparticles resting on viscoelastic foundation

Abolfazl Jafari Natanzi,Gholamreza Soleimani Jafari,Reza Kolahchi 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.5

In this study, nonlinear vibration and stability of a polymeric pipe reinforced by single-walled carbon naotubes (SWCNTs) conveying fluid-nanoparticles mixture flow is investigated. The Characteristics of the equivalent composite are determined using Mori-Tanaka model considering agglomeration effects. The surrounding elastic medium is simulated by orthotropic visco-Pasternak medium. Employing nonlinear strains-displacements, stress-strain energy method the governing equations were derived using Hamilton's principal. Differential quadrature method (DQM) is used for obtaining the frequency and critical fluid velocity. The influence of volume percent of SWCNTs, agglomeration, geometrical parameters of pipe, viscoelastic foundation and fluid velocity are shown on the frequency and critical fluid velocity of pipe. Results showed the increasing volume percent of SWCNTs leads to higher frequency and critical fluid velocity.

Phage Particles as Vaccine Delivery Vehicles: Concepts, Applications and Prospects

Jafari, Narjes,Abediankenari, Saeid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

The development of new strategies for vaccine delivery for generating protective and long-lasting immune responses has become an expanding field of research. In the last years, it has been recognized that bacteriophages have several potential applications in the biotechnology and medical fields because of their intrinsic advantages, such as ease of manipulation and large-scale production. Over the past two decades, bacteriophages have gained special attention as vehicles for protein/peptide or DNA vaccine delivery. In fact, whole phage particles are used as vaccine delivery vehicles to achieve the aim of enhanced immunization. In this strategy, the carried vaccine is protected from environmental damage by phage particles. In this review, phage-based vaccine categories and their development are presented in detail, with discussion of the potential of phage-based vaccines for protection against microbial diseases and cancer treatment. Also reviewed are some recent advances in the field of phagebased vaccines.

Trends of Breast Cancer Incidence in Iran During 2004-2008: A Bayesian Space-time Model

Jafari-Koshki, Tohid,Schmid, Volker Johann,Mahaki, Behzad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: Breast cancer is the most frequently diagnosed cancer in women and estimating its relative risks and trends of incidence at the area-level is helpful for health policy makers. However, traditional methods of estimation which do not take spatial heterogeneity into account suffer from drawbacks and their results may be misleading, as the estimated maps of incidence vary dramatically in neighboring areas. Spatial methods have been proposed to overcome drawbacks of traditional methods by including spatial sources of variation in the model to produce smoother maps. Materials and Methods: In this study we analyzed the breast cancer data in Iran during 2004-2008. We used a method proposed to cover spatial and temporal effects simultaneously and their interactions to study trends of breast cancer incidence in Iran. Results: The results agree with previous studies but provide new information about two main issues regarding the trend of breast cancer in provinces of Iran. First, this model discovered provinces with high relative risks of breast cancer during the 5 years of the study. Second, new information was provided with respect to overall trend trends o. East-Azerbaijan, Golestan, North-Khorasan, and Khorasan-Razavi had the highest increases in rates of breast cancer incidence whilst Tehran, Isfahan, and Yazd had the highest incidence rates during 2004-2008. Conclusions: Using spatial methods can provide more accurate and detailed information about the incidence or prevalence of a disease. These models can specify provinces with different health priorities in terms of needs for therapy and drugs or demands for efficient education, screening, and preventive policy into action.

Participation of the Women Covered by Family Physicians in Breast Cancer Screening Program in Kerman, Iran

Jafari, Mohammad,Nakhaee, Nouzar,Goudarzi, Reza,Zehtab, Nooshin,Barouni, Mohsen Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: Mammography screening is a method for reducing breast cancer mortality in women over 40 years old. A participation rate of at least 70% is a prerequisite for screening programs. This study aimed at determining the participation rate of women in breast cancer screening in Iran. Materials and Methods: The study population in this prospective research consisted of 35 to 69 years old women in the villages and towns Kerman District, in 2013. The data were collected by a well-validated risk assessment questionnaire. The questionnaires were completed with the help of health workers and technicians in the health centers, who were trained on breast cancer screening program. Results: As a whole, 19,651 women were invited to complete the questionnaire, of whom 15,794 women (80.37%) completed it. In the urban region, of 3150 eligible women 2728 women (86.60%) participated in the study. The acceptance rates for mammography in rural and urban regions were 34.95% and 8.75%, respectively. Conclusions: Finally, 3.8% and 16.34% of 35 to 69 years old women in the urban regions were mammographed, respectively. Conclusion: The low participation of eligible women in breast cancer screening program alerts us against including the program in the health insurance package.

Determination of bortezomib and dasatinib anticancer drugs in real samples using an electrochemical sensor modified with new CuFe2O4/SmVO4/ionic liquid nanocomposite

Jafari-Kashi Abbas,Shabani-Nooshabadi Mehdi,Rafiee-Pour Hossain-Ali 한국탄소학회 2024 Carbon Letters Vol.34 No.3

Bortezomib (BTZ) and dasatinib (DA) are two substantial anti-cancer agents with side effects on the human body. In this research, we fabricated a novel electrochemical sensor modified by CuFe2O4/SmVO4 nanocomposite and 1-ethyl-3-methylimidazolium chloride (1E3MC) as an ionic liquid (IL) (CuFe2O4/SmVO4/IL/CPE) for coinciding investigation of BTZ and DA for the first time. The CuFe2O4/SmVO4 synthesized were determined and certified through field-emission scanning electron microscopy (FE-SEM), energy diffraction X-ray (EDX), and X-ray diffraction (XRD). The capability of the sensor was investigated by different electrochemical techniques such as cyclic voltammetry (CV), chronoamperometry (CHA), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The attained data showed that the oxidation signal of bortezomib and dasatinib promoted as an innovative electrochemical sensor. After optimization of the conditions using this sensor at pH 7.0, the oxidation signal of bortezomib and dasatinib showed to be linear with drug concentrations in the range of 0.09–90 µM and 100–500 µM with a detection limit of 5.4 nM and 7.0 µM, respectively, using differential pulse voltammetry method. The values of D and electro-transfer coefficient (α) achieved 2.5 × 10−5 cm2 s−1 and 0.99, respectively. The proposed electrochemical sensor exhibited acceptable selectivity and sensitivity for simultaneous detection of bortezomib and dasatinib in pharmaceutical and biological samples.

Light transmittance of CAD/CAM ceramics with different shades and thicknesses and microhardness of the underlying light-cured resin cement

Jafari, Zahra,Alaghehmand, Homayoon,Samani, Yasaman,Mahdian, Mina,Khafri, Soraya The Korean Academy of Conservative Dentistry 2018 Restorative Dentistry & Endodontics Vol.43 No.3

Objectives: The aim of this in vitro study was to evaluate the effects of the thickness and shade of 3 types of computer-aided design/computer-aided manufacturing (CAD/CAM) materials. Materials and Methods: A total of 120 specimens of 2 shades (A1 and A3) and 2 thicknesses (1 and 2 mm) were fabricated using VITA Mark II (VM; VITA Zahnfabrik), IPS e.max CAD (IE; IvoclarVivadent), and VITA Suprinity (VS; VITA Zahnfabrik) (n = 10 per subgroup). The amount of light transmission through the ceramic specimens was measured by a radiometer (Optilux, Kerr). Light-cured resin cement samples (Choice 2, Bisco) were fabricated in a Teflon mold and activated through the various ceramics with different shades and thicknesses using an LED unit (Bluephase, IvoclarVivadent). In the control group, the resin cement sample was directly light-cured without any ceramic. Vickers microhardness indentations were made on the resin surfaces (KoopaPazhoohesh) after 24 hours of dark storage in a $37^{\circ}C$ incubator. Data were analyzed using analysis of variance followed by the Tukey post hoc test (${\alpha}=0.05$). Results: Ceramic thickness and shade had significant effects on light transmission and the microhardness of all specimens (p < 0.05). The mean values of light transmittance and microhardness of the resin cement in the VM group were significantly higher than those observed in the IE and VS groups. The lowest microhardness was observed in the VS group, due to the lowest level of light transmission (p < 0.05). Conclusion: Greater thickness and darker shades of the 3 types of CAD/CAM ceramics significantly decreased the microhardness of the underlying resin cement.

Real-Time Operation of Pumping Systems for Urban Flood Mitigation: Single-Period vs. Multi-Period Optimization

Jafari, Fatemeh,Jamshid Mousavi, S.,Yazdi, Jafar,Kim, Joong Hoon Springer-Verlag 2018 Water resources management Vol.32 No.14

Optimizing Bi-Objective Multi-Echelon Multi-Product Supply Chain Network Design Using New Pareto-Based Approaches

Jafari, Hamid Reza,Seifbarghy, Mehdi Korean Institute of Industrial Engineers 2016 Industrial Engineeering & Management Systems Vol.15 No.4

The efficiency of a supply chain can be extremely affected by its design which includes determining the flow pattern of material from suppliers to costumers, selecting the suppliers, and defining the opened facilities in network. In this paper, a multi-objective multi-echelon multi-product supply chain design model is proposed in which several suppliers, several manufacturers, several distribution centers as different stages of supply chain cooperate with each other to satisfy various costumers' demands. The multi-objectives of this model which considered simultaneously are 1-minimize the total cost of supply chain including production cost, transportation cost, shortage cost, and costs of opening a facility, 2-minimize the transportation time from suppliers to costumers, and 3-maximize the service level of the system by minimizing the maximum level of shortages. To configure this model a graph theoretic approach is used by considering channels among each two facilities as links and each facility as the nodes in this configuration. Based on complexity of the proposed model a multi-objective Pareto-based vibration damping optimization (VDO) algorithm is applied to solve the model and finally non-dominated sorting genetic algorithm (NSGA-II) is also applied to evaluate the performance of MOVDO. The results indicated the effectiveness of the proposed MOVDO to solve the model.

ON THE NUMBER OF CYCLIC SUBGROUPS OF A FINITE GROUP

Jafari, Mohammad Hossein,Madadi, Ali Reza Korean Mathematical Society 2017 대한수학회보 Vol.54 No.6

Let G be a finite group and m a divisor of ${\mid}G{\mid}$. We prove that G has at least ${\tau}(m)$ cyclic subgroups whose orders divide m, where ${\tau}(m)$ is the number of divisors of m.