http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jacobus N. Eloff (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Jean Paul Dzoyem,Antoine H. L. Nkuete,Barthelemy Ngameni,Jacobus N. Eloff 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
This study was aimed at investigating the antiinflammatoryand anticholinesterase activity of six naturallyoccurring flavonoids: (2) pinostrobin (1), 20,40-dihydroxy-30,60-dimethoxychalcone (2), 6-8-diprenyleriodictyol (3),isobavachalcone (4), 4-hydroxylonchocarpin (5) and6-prenylapigenin (6). These compounds were isolated fromDorstenia and Polygonum species used traditionally to treatpain. The anti-inflammatory activity was determined by usingthe Griess assay and the 15-lipoxygenase inhibitory activitywas determined with the ferrous oxidation-xylenolorange assay. Acetylcholinesterase inhibition was determinedby the Ellman’s method. At the lowest concentrationtested (3.12 lg/ml), compounds 2, 3 and 4 had significantNO inhibitory activity with 90.71, 84.65 and 79.57 % inhibitionrespectively compared to the positive controlquercetin (67.93 %). At this concentration there was nosignificant cytotoxicity against macrophages with 91.67,72.86 and 70.86 % cell viability respectively, compared to73.1 % for quercetin. Compound 4 had the most potentlipoxygenase inhibitory activity (IC50 of 25.92 lg/ml). Withthe exception of (2) pinostrobin (1), all the flavonoids hadselective anticholinesterase activity with IC50 values rangingbetween 5.93 and 8.76 lg/ml compared to the IC50 4.94 lg/ml of eserine the positive control. These results indicate thatthe studied flavonoids especially isobavachalcone are potentialanti-inflammatory natural products that may have thepotential to be developed as therapeutic agents against inflammatoryconditions and even Alzheimer’s disease.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
